STANDARD_NAME	WAKASUGI_HAVE_ZNF143_BINDING_SITES
SYSTEMATIC_NAME	M9575
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WAKASUGI_HAVE_ZNF143_BINDING_SITES
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites.
DESCRIPTION_FULL	Zinc-finger protein 143 (ZNF143) is a human homolog of Xenopus transcriptional activator staf that is involved in selenocystyl tRNA transcription. We previously showed that ZNF143 expression is induced by treatment with DNA-damaging agents and that it preferentially binds to cisplatin-modified DNA. In this study, the potential function of ZNF143 was investigated. ZNF143 was overexpressed in cisplatin-resistant cells. ZNF143 knockdown in prostate cancer caused increased sensitivity for cisplatin, but not for oxaliplatin, etoposide and vincristine. We also showed that ZNF143 is associated with tumor suppressor gene product p73 but not with p53. p73 could stimulate the binding of ZNF143 to both ZNF143 binding site and cisplatin-modified DNA, and modulate the function of ZNF143. We provide a direct evidence that both Rad51 and flap endonuclease-1 are target genes of ZNF143 and overexpressed in cisplatin-resistant cells. Taken together, these experiments demonstrate that an interplay of ZNF143, p73 and ZNF143 target genes is involved in DNA repair gene expression and cisplatin resistance.
PMID	17297437
GEOID	
AUTHORS	Wakasugi T,Izumi H,Uchiumi T,Suzuki H,Arao T,Nishio K,Kohno K
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	APEX1,APTX,BRCA1,CHEK1,CHEK2,CKN1,DDB1,DSS1,ERCC1,ERCC4,EXO1,FANCB,FANCD2,FANCE,FANCG,FANCL,FEN1,GTF2H4,GTF2H5,HEL308,HR23B,LIG4,MRE11A,MSH2,MSH3,MSH4,MSH5,MSH6,MUS81,MYH,NEIL2,NTH1,p53R2,PMS1,PMS2,POLB,POLD1,POLE,POLI,POLK,PRKDC,RAD1,RAD18,RAD23A,RAD23B,Rad50,Rad51,Rad51C,Rad51L1,Rad52,RAD9A,RECQL,RECQL4,RECQL5,REV1L,REV3L,RRM2B,SHFM1,TDG,TDP1,TP53,TTDA,UBE2N,XPC
GENE_SYMBOLS	APEX1,APTX,BRCA1,CHEK1,CHEK2,ERCC8,DDB1,SEM1,ERCC1,ERCC4,EXO1,FANCB,FANCD2,FANCE,FANCG,FANCL,FEN1,GTF2H4,GTF2H5,,RAD23B,LIG4,MRE11,MSH2,MSH3,MSH4,MSH5,MSH6,MUS81,MUTYH,NEIL2,NTHL1,PMS1,PMS2,POLB,POLD1,POLE,POLI,POLK,PRKDC,RAD1,RAD18,RAD23A,RAD23B,RAD9A,RECQL,RECQL4,RECQL5,REV1,REV3L,RRM2B,,,,,,SEM1,TDG,TDP1,TP53,GTF2H5,UBE2N,XPC,RRM2B
FOUNDER_NAMES