STANDARD_NAME	WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN
SYSTEMATIC_NAME	M707
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes down-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue.
DESCRIPTION_FULL	PURPOSE: To elucidate the molecular mechanisms contributing to the unique clinicopathologic characteristics of mucinous ovarian carcinoma, global gene expression profiling of mucinous ovarian tumors was carried out. EXPERIMENTAL DESIGN: Gene expression profiling was completed for 25 microdissected mucinous tumors [6 cystadenomas, 10 low malignant potential (LMP) tumors, and 9 adenocarcinomas] using Affymetrix U133 Plus 2.0 oligonucleotide microarrays. Hierarchical clustering and binary tree prediction analysis were used to determine the relationships among mucinous specimens and a series of previously profiled microdissected serous tumors and normal ovarian surface epithelium. PathwayAssist software was used to identify putative signaling pathways involved in the development of mucinous LMP tumors and adenocarcinomas. RESULTS: Comparison of the gene profiles between mucinous tumors and normal ovarian epithelial cells identified 1,599, 2,916, and 1,765 differentially expressed in genes in the cystadenomas, LMP tumors, and adenocarcinomas, respectively. Hierarchical clustering showed that mucinous and serous LMP tumors are distinct. In addition, there was a close association of mucinous LMP tumors and adenocarcinomas with serous adenocarcinomas. Binary tree prediction revealed increased heterogeneity among mucinous tumors compared with their serous counterparts. Furthermore, the cystadenomas coexpressed a subset of genes that were differentially regulated in LMP and adenocarcinoma specimens compared with normal ovarian surface epithelium. PathwayAssist highlighted pathways with expression of genes involved in drug resistance in both LMP and adenocarcinoma samples. In addition, genes involved in cytoskeletal regulation were specifically up-regulated in the mucinous adenocarcinomas. CONCLUSIONS: These data provide a useful basis for understanding the molecular events leading to the development and progression of mucinous ovarian cancer.
PMID	16467078
GEOID	
AUTHORS	Wamunyokoli FW,Bonome T,Lee JY,Feltmate CM,Welch WR,Radonovich M,Pise-Masison C,Brady J,Hao K,Berkowitz RS,Mok S,Birrer MJ
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1554007_at,200986_at,201117_s_at,201278_at,201280_s_at,201315_x_at,201578_at,201581_at,201591_s_at,201811_x_at,201849_at,202157_s_at,202391_at,202948_at,203074_at,203445_s_at,203650_at,203851_at,203854_at,203934_at,204359_at,204457_s_at,204466_s_at,204646_at,204959_at,205003_at,206067_s_at,208666_s_at,208788_at,208933_s_at,208935_s_at,209291_at,209568_s_at,210561_s_at,211276_at,211696_x_at,212097_at,212119_at,212120_at,212136_at,212266_s_at,212353_at,212558_at,213056_at,213058_at,213135_at,213317_at,213939_s_at,214428_x_at,214945_at,217317_s_at,217767_at,218694_at,218709_s_at,218901_at,219304_s_at,219639_x_at,221768_at,221872_at,221899_at,222482_at,226425_at,226509_at,226679_at,226773_at,226875_at,227279_at,227554_at,227708_at,230130_at,230180_at,230387_at,230661_at,231906_at,232118_at,232568_at,235210_s_at,235759_at,238669_at,56197_at
GENE_SYMBOLS	ZNF483,SERPING1,CPE,DAB2,DAB2,IFITM2,PODXL,TMX4,NISCH,SH3BP5,BNIP3,CELF2,BASP1,IL1R1,ANXA8,CTDSP2,PROCR,IGFBP6,CFI,KDR,FLRT2,GAS1,SNCA,DPYD,MNDA,DOCK4,WT1,ST13,ELOVL5,LGALS8,LGALS8,ID4,RGL1,WSB1,TCEAL2,HBB,CAV1,RHOQ,RHOQ,ATP2B4,SRSF5,SULF1,SPRY1,FRMD4B,TTC28,TIAM1,CLIC5,RUFY3,C4A,FAM153A,HERC2P9,C3,ARMCX1,IFT52,PLSCR4,PDGFD,PARP6,SFPQ,RARRES1,N4BP2L2,SSBP3,CLIP4,ZNF641,SLC26A11,PPM1K,DOCK11,TCEAL3,MAGI2-AS3,EEF1A1,,DDX17,,SBSPON,HOXD8,LRRN4,,SBSPON,,PTGS1,PLSCR3
FOUNDER_NAMES