STANDARD_NAME	WANG_LSD1_TARGETS_UP
SYSTEMATIC_NAME	M1759
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WANG_LSD1_TARGETS_UP
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary.
DESCRIPTION_FULL	Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One thing that remains unclear is how specific members of histone modification enzyme families, such as histone methyltransferases and demethylases, are used in vivo to simultaneously orchestrate distinct developmental gene activation and repression programmes. Here, we report that the histone lysine demethylase, LSD1--a component of the CoREST-CtBP co-repressor complex--is required for late cell-lineage determination and differentiation during pituitary organogenesis. LSD1 seems to act primarily on target gene activation programmes, as well as in gene repression programmes, on the basis of recruitment of distinct LSD1-containing co-activator or co-repressor complexes. LSD1-dependent gene repression programmes can be extended late in development with the induced expression of ZEB1, a Krüppel-like repressor that can act as a molecular beacon for recruitment of the LSD1-containing CoREST-CtBP co-repressor complex, causing repression of an additional cohort of genes, such as Gh, which previously required LSD1 for activation. These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs.
PMID	17392792
GEOID	
AUTHORS	Wang J,Scully K,Zhu X,Cai L,Zhang J,Prefontaine GG,Krones A,Ohgi KA,Zhu P,Garcia-Bassets I,Liu F,Taylor H,Lozach J,Jayes FL,Korach KS,Glass CK,Fu XD,Rosenfeld MG
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Fig 4AS
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1110033J19Rik,2410012A13Rik,Ccne1,Cd1d1,Cdkn1c,Csrp2,Dutt1,Elk3,Epb4.1l2,Foxg1,Gadd45g,Gas6,Heph,hey1,Igfbp2,Igfbp5,Lgals1,Lmyc1,Mdk,Mgp,otx2,Pdgfa,Pycard,Reln,Six1,Sox2,Tgfb2,Vil2
GENE_SYMBOLS	,RPRM,CCNE1,CD1D,CDKN1C,CSRP2,,ELK3,EPB41L2,FOXG1,GADD45G,GAS6,HEPH,IGFBP2,IGFBP5,LGALS1,MYCL,MDK,MGP,PDGFA,PYCARD,RELN,SIX1,SOX2,TGFB2,EZR,,
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