STANDARD_NAME WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN SYSTEMATIC_NAME M2132 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932]. DESCRIPTION_FULL Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. PMID 20541704 GEOID GSE19736 AUTHORS Wang Z,Iwasaki M,Ficara F,Lin C,Matheny C,Wong SH,Smith KS,Cleary ML CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: Downregulated genes FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAT2,ACSL1,ACSL3,ACTL6A,ACY1,AHSA1,ALDH1A3,ALDH1B1,ALOX12,ANKRD28,APBB1,ARHGAP21,ARL4C,ARRB1,ASF1B,ATAD2,ATAD3B,B4GALT2,BEX1,BLM,BRCA1,BRIP1,BUB1,BUB1B,BYSL,C10orf2,C11orf58,C11orf82,C12orf44,C13orf27,C13orf31,C15orf23,C15orf42,C1orf93,CABC1,CABLES1,CASC5,CCDC26,CCDC28A,CCDC64,CCM2,CCNA2,CCNE1,CCNE2,CCPG1,CCR1,CCR2,CD151,CD180,CD38,CDC25A,CDC42EP3,CDC45L,CDC6,CDCA4,CDK2,CECR5,CENPH,CENPK,CENPM,CEP76,CHAF1A,CHAF1B,CHST11,CITED2,CKS1B,CLSPN,CTDSPL,CTPS,CYP51A1,DARS2,DBN1,DCUN1D5,DERL3,DHCR24,DHCR7,DHFR,DIAPH3,DISP2,DKC1,DLX1,DNAJA1,DNAJC19,DPH2,DSCC1,DTL,DUSP6,DYSFIP1,E2F2,E2F7,E2F8,EAPP,EBNA1BP2,EBP,ECE1,EGR1,EHD1,EIF4EBP1,EIF5AL1,EMP2,ERO1L,ESCO2,ETV4,ETV5,EXO1,EXOSC4,EXOSC5,EZR,F2RL3,FABP5,FADS2,FAM100A,FAM100B,FAM136A,FAM32A,FAM46C,FAM60A,FASN,FEN1,FKBP4,FOS,FOXJ3,FREQ,FUT7,GABPA,GABPB2,GART,GEMIN4,GGT5,GINS1,GINS2,GINS3,GINS4,GK,GMEB1,GMFG,GMNN,GNB4,GOLGA9P,GPT2,H2AFX,H2AFZ,HELLS,HERPUD1,HIST1H1B,HIST1H1E,HIST1H2AB,HIST1H2AI,HIST1H2BB,HIST1H2BM,HIST1H3J,HIST1H4B,HMGB3,HMGCS1,HN1L,HNRNPAB,HSP90AA1,HSPA1A,HSPA1B,HSPA4L,HSPC111,HSPE1,HSPH1,IDI1,IGFBP4,IGLL3,IL1RAP,IL3RA,INSIG1,IPO11,ISYNA1,ITGA4,ITGA5,ITGB5,KCNN4,KIAA0133,KIAA0746,KIAA1147,KIAA1524,KIF21B,KIF22,KIF23,KLHDC2,KLHDC3,LAS1L,LBR,LDLR,LGALS12,LMO2,LOC100130876,LOC1720,LOC344967,LOC348840,LOC388022,LOC389523,LOC389842,LOC400506,LOC642521,LOC642538,LOC85389,LOC85391,LPCAT1,LRP8,LY6E,LYAR,MAD2L1,MAF1,MASTL,MATK,MCAT,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MCM8,MELK,MIF,MIRN155,MLF1IP,MOBKL2A,MOCS3,MPP6,MRPS12,MRTO4,MSH2,MSH6,MSN,MTBP,MYBL2,MYC,N6AMT2,NASP,NCAPD3,NCAPG,NCF1,NDRG1,NIP7,NLRP3,NOL6,NOLA2,NUDT5,NUF2,ORC6L,PAIP2,PBK,PDCD4,PDGFA,PDK1,PELI2,PFKP,PHF15,PHLDA1,PIGW,PIH1D1,PIM1,PIM2,PKMYT1,PLK4,PLXNA1,PNO1,POLA1,POLE2,POLR3H,PREB,PRPS1,PRR6,PSAT1,PSCDBP,PSMC3IP,PTPN7,PTPRE,PTTG1,PUS7,PYCRL,RAB18,RAD51,RAD51AP1,RAD54L,RANBP1,RASGRP2,RB1CC1,RFC2,RFC3,RFTN1,RFWD3,RG9MTD1,RHBDL3,RICH2,RNF122,RNF144A,RNMT,RNU13P2,RPS6KA5,RRM2,RRP12,RRP7A,RUVBL1,SC4MOL,SCD,SDF2L1,SEH1L,SERPINB8,SFXN1,SHCBP1,SIGLEC12,SLC16A1,SLC1A4,SLC25A19,SLC27A2,SLC2A1,SLC2A3,SLC2A5,SLC38A2,SLC38A5,SLC39A14,SLC6A6,SLC7A5,SLC9A3R1,SLCO4A1,SMC2,SNRPG,SPC24,SPC25,SPIN4,SQLE,ST8SIA4,STMN1,SUV39H1,SYT2,TAF4B,TBC1D15,TCEB3,TCF19,TCTN2,TDRKH,TFAM,TFB2M,TFDP2,TFRC,TGFBR1,THOC4,TIMP3,TIPARP,TIPIN,TK1,TLE4,TLR2,TNF,TNFAIP3,TOE1,TRIP13,TSFM,TSR1,TUBA4A,TYMS,UBE2T,UHRF1,UMPS,UNC84B,UNG,UNQ353,UTP15,WDR4,WDR48,WEE1,WIT1,WT1,XBP1,XRCC2,XTP3TPA,ZNF367,ZWINT GENE_SYMBOLS ACAT2,ACSL1,ACSL3,ACTL6A,ACY1,AHSA1,ALDH1A3,ALDH1B1,ALOX12,ANKRD28,APBB1,ARHGAP21,ARL4C,ARRB1,ASF1B,ATAD2,ATAD3B,B4GALT2,BEX1,BLM,BRCA1,BRIP1,BUB1,BUB1B,BYSL,TWNK,C11orf58,DDIAS,ATG101,TEX30,LACC1,KNSTRN,TICRR,PRXL2B,COQ8A,CABLES1,KNL1,CCDC26,CCDC28A,BICDL1,CCM2,CCNA2,CCNE1,CCNE2,CCPG1,CCR1,CCR2,CD151,CD180,CD38,CDC25A,CDC42EP3,CDC45,CDC6,CDCA4,CDK2,HDHD5,CENPH,CENPK,CENPM,CEP76,CHAF1A,CHAF1B,CHST11,CITED2,CKS1B,CLSPN,CTDSPL,CTPS1,CYP51A1,DARS2,DBN1,DCUN1D5,DERL3,DHCR24,DHCR7,DHFR,DIAPH3,DISP2,DKC1,DLX1,DNAJA1,DNAJC19,DPH2,DSCC1,DTL,DUSP6,PPP1R27,E2F2,E2F7,E2F8,EAPP,EBNA1BP2,EBP,ECE1,EGR1,EHD1,EIF4EBP1,EIF5AL1,EMP2,ERO1A,ESCO2,ETV4,ETV5,EXO1,EXOSC4,EXOSC5,EZR,F2RL3,FABP5,FADS2,UBALD1,UBALD2,FAM136A,FAM32A,TENT5C,SINHCAF,FASN,FEN1,FKBP4,FOS,FOXJ3,NCS1,FUT7,GABPA,GABPB2,GART,GEMIN4,GGT5,GINS1,GINS2,GINS3,GINS4,GK,GMEB1,GMFG,GMNN,GNB4,GOLGA8IP,GPT2,H2AX,H2AZ1,HELLS,HERPUD1,H1-5,H1-4,H2AC4,H2AC13,H2BC3,H2BC14,H3C12,H4C2,HMGB3,HMGCS1,JPT2,HNRNPAB,HSP90AA1,HSPA1A,HSPA1B,HSPA4L,NOP16,HSPE1,HSPH1,IDI1,IGFBP4,IGLL3P,IL1RAP,IL3RA,INSIG1,IPO11,ISYNA1,ITGA4,ITGA5,ITGB5,KCNN4,URB2,SEL1L3,DENND11,CIP2A,KIF21B,KIF22,KIF23,KLHDC2,KLHDC3,LAS1L,LBR,LDLR,LGALS12,LMO2,,DHFRP3,ENSG00000205794,ANKRD18DP,,CASTOR2,RANBP1P1,KNOP1,C1DP3,C1DP2,SNORD14C,SNORD14E,LPCAT1,LRP8,LY6E,LYAR,MAD2L1,MAF1,MASTL,MATK,MCAT,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MCM8,MELK,MIF,MIR155,CENPU,MOB3A,MOCS3,PALS2,MRPS12,MRTO4,MSH2,MSH6,MSN,MTBP,MYBL2,MYC,EEF1AKMT1,NASP,NCAPD3,NCAPG,NCF1,NDRG1,NIP7,NLRP3,NOL6,NHP2,NUDT5,NUF2,ORC6,PAIP2,PBK,PDCD4,PDGFA,PDK1,PELI2,PFKP,JADE2,PHLDA1,PIGW,PIH1D1,PIM1,PIM2,PKMYT1,PLK4,PLXNA1,PNO1,POLA1,POLE2,POLR3H,PREB,PRPS1,CENPV,PSAT1,CYTIP,PSMC3IP,PTPN7,PTPRE,PTTG1,PUS7,PYCR3,RAB18,RAD51,RAD51AP1,RAD54L,RANBP1,RASGRP2,RB1CC1,RFC2,RFC3,RFTN1,RFWD3,TRMT10C,RHBDL3,ARHGAP44,RNF122,RNF144A,RNMT,,RPS6KA5,RRM2,RRP12,RRP7A,RUVBL1,MSMO1,SCD,SDF2L1,SEH1L,SERPINB8,SFXN1,SHCBP1,SIGLEC12,SLC16A1,SLC1A4,SLC25A19,SLC27A2,SLC2A1,SLC2A3,SLC2A5,SLC38A2,SLC38A5,SLC39A14,SLC6A6,SLC7A5,NHERF1,SLCO4A1,SMC2,SNRPG,SPC24,SPC25,SPIN4,SQLE,ST8SIA4,STMN1,SUV39H1,SYT2,TAF4B,TBC1D15,ELOA,TCF19,TCTN2,TDRKH,TFAM,TFB2M,TFDP2,TFRC,TGFBR1,ALYREF,TIMP3,TIPARP,TIPIN,TK1,TLE4,TLR2,TNF,TNFAIP3,TOE1,TRIP13,TSFM,TSR1,TUBA4A,TYMS,UBE2T,UHRF1,UMPS,SUN2,UNG,,UTP15,WDR4,WDR48,WEE1,WT1-AS,WT1,XBP1,XRCC2,DCTPP1,ZNF367,ZWINT FOUNDER_NAMES