STANDARD_NAME	WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_DN
SYSTEMATIC_NAME	M15662
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes down-regulated in non-neoplastic rectal mucosa samples from patients having cancer associated with ulcerative collitis, compared to those who did not have the cancer.
DESCRIPTION_FULL	PURPOSE: Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development of cancer in UC, we conducted a DNA microarray analysis using nonneoplastic rectal mucosa of UC patients. EXPERIMENTAL DESIGN: Gene expression in nonneoplastic mucosa of 53 UC patients were examined. Gene expression profiles were examined using human Genome U133 Plus 2.0 gene chip array (Affymetrix). Among 53 UC patients, 10 had UC-associated cancer (UC-Ca group) whereas 43 did not (UC-NonCa group). RESULTS: By comparing gene expression profiles of nonneoplastic rectal mucosae between the UC-Ca and UC-NonCa groups, we could identify 40 genes that were differentially expressed between two groups. The list of discriminating genes included low-density lipoprotein receptor-related protein (LRP5 and LRP6). Previous studies suggested that LRP5 and LRP6 expression promotes cancer cell proliferation and tumorigenesis and are considered as candidate oncogenes. In the present study, both LRP5 and LRP6 showed significantly higher expression in the UC-Ca group, which suggests the importance of these genes in the development of UC-associated colorectal cancers. With the 40 selected discriminating genes, we did class prediction of the development of colorectal neoplasms in UC patients. Using the k-nearest neighbor method and the support vector machine, we could predict the development of UC-associated neoplasms with an accuracy of 86.8% and 98.1%, respectively. CONCLUSIONS: These findings have important implications for the early detection of malignant lesions in UC and may provide directions for future research into the molecular mechanisms of UC-associated cancer.
PMID	17255260
GEOID	GSE3629
AUTHORS	Watanabe T,Kobunai T,Toda E,Kanazawa T,Kazama Y,Tanaka J,Tanaka T,Yamamoto Y,Hata K,Kojima T,Yokoyama T,Konishi T,Okayama Y,Sugimoto Y,Oka T,Sasaki S,Ajioka Y,Muto T,Nagawa H
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1555638_a_at,1560706_at,202269_x_at,203760_s_at,203819_s_at,205270_s_at,206974_at,209770_at,217629_at,220330_s_at,224909_s_at,226080_at,226153_s_at,226474_at,229625_at,231577_s_at,231747_at,235175_at,238581_at,239946_at
GENE_SYMBOLS	SAMSN1,NEDD9,GBP1,SLA,IGF2BP3,LCP2,CXCR6,BTN3A1,GNGT2,SAMSN1,PREX1,SSH2,CNOT6L,NLRC5,GBP5,GBP1,CYSLTR1,GBP4,GBP5,
FOUNDER_NAMES