STANDARD_NAME	WEINMANN_ADAPTATION_TO_HYPOXIA_UP
SYSTEMATIC_NAME	M11948
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WEINMANN_ADAPTATION_TO_HYPOXIA_UP
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes most up-regulated in hypoxia tolerant NCI H460 cells (lung cancer).
DESCRIPTION_FULL	Tumor hypoxia is an adverse prognostic factor. In a recent study, we could demonstrate that cyclic hypoxia selects for hypoxia-tolerant tumor cells, which are cross-resistant to other stimuli of mitochondrial death pathways. In contrast, sensitivity of the cells to death-receptor ligands was mainly not affected. The aim of the present study was to further elucidate cellular changes induced by cyclic hypoxia and to identify alterations in gene expression pattern upon hypoxic selection by means of DNA-microarray analysis. Our data reveal that cyclic hypoxia resulted in the selection of cells with resistance to doxorubicine and radiation. Furthermore, hypoxic selection was accompanied by constitutive changes of the gene expression pattern with downregulation of 156 and upregulation of 82 genes. Most of the differentially regulated genes were involved in cellular responses to hypoxia and reoxygenation. While many of the genes that were downregulated upon hypoxic selection represent genes that are usually upregulated by acute hypoxia, the genes that were upregulated represent genes that are involved in stress resistance and anti-apoptotic signalling. Most importantly, hypoxic selection was not associated with changes of single apoptosis relevant genes, but with alterations in gene expression levels of a wide variety of genes indicating a more complex adaptation process.
PMID	15897868
GEOID	
AUTHORS	Weinmann M,Belka C,Güner D,Goecke B,Müller I,Bamberg M,Jendrossek V
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2a, 2d
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AF116273,AF130082,AU144167,AW149846,BC000454,NM_000237,NM_000366,NM_000691,NM_000903,NM_001512,NM_001553,NM_001855,NM_002133,NM_002167,NM_002245,NM_002356,NM_002402,NM_002758,NM_004010,NM_004207,NM_004750,NM_005346,NM_006169,NM_006305,NM_006670,NM_006681,NM_014059,NM_014333,U56725,U87460
GENE_SYMBOLS	BAG1,,COL3A1,,CALM1,LPL,TPM1,ALDH3A1,NQO1,GSTA4,IGFBP7,COL15A1,HMOX1,ID3,KCNK1,MARCKS,MEST,MAP2K6,DMD,SLC16A3,CRLF1,HSPA1B,NNMT,ANP32A,TPBG,NMU,RGCC,CADM1,,
FOUNDER_NAMES