STANDARD_NAME WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP SYSTEMATIC_NAME M205 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Top up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. DESCRIPTION_FULL Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. Differences in gene expression were also identified between adrenocortical adenomas and carcinomas. In addition, pediatric adrenocortical carcinomas were found to share similar patterns of gene expression when compared with those published for adult ACT. This study represents the first microarray analysis of childhood ACT. Our findings lay the groundwork for establishing gene expression profiles that may aid in the diagnosis and prognosis of pediatric ACT, and in the identification of signaling pathways that contribute to this disease. PMID 17234769 GEOID AUTHORS West AN,Neale GA,Pounds S,Figueredo BC,Rodriguez Galindo C,Pianovski MA,Oliveira Filho AG,Malkin D,Lalli E,Ribeiro R,Zambetti GP CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2: Increased FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 201291_s_at,201292_at,201890_at,202410_x_at,202779_s_at,203213_at,203708_at,203828_s_at,204056_s_at,204285_s_at,204597_x_at,204641_at,205345_at,207414_s_at,209218_at,210881_s_at,211237_s_at,213126_at,213479_at,213562_s_at,218009_s_at,218585_s_at,218755_at,219918_s_at,220091_at GENE_SYMBOLS TOP2A,TOP2A,RRM2,IGF2,UBE2S,CDK1,PDE4B,IL32,MVK,PMAIP1,STC1,NEK2,BARD1,PCSK6,SQLE,IGF2,FGFR4,MED8,NPTX2,SQLE,PRC1,DTL,KIF20A,ASPM,SLC2A6 FOUNDER_NAMES