STANDARD_NAME	WOOD_EBV_EBNA1_TARGETS_UP
SYSTEMATIC_NAME	M1696
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WOOD_EBV_EBNA1_TARGETS_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in the Ad/AH cells (adenocarcinoma) engineered to stably express the Epstein-Barr virus (EBV) gene EBNA1.
DESCRIPTION_FULL	The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all virus-associated tumors where it plays an essential role in the maintenance, replication and transcription of the EBV genome. Transcriptional profiling of EBNA1-expressing carcinoma cells demonstrated that EBNA1 also influences the expression of a range of cellular genes including those involved in translation, transcription and cell signaling. Of particular interest was the ability of EBNA1 to enhance expression of STAT1 and sensitize cells to interferon-induced STAT1 activation with resultant enhancement of major histocompatibility complex expression. A negative effect of EBNA1 on the expression of TGFbeta1-responsive betaig-h3 and PAI-1 genes was confirmed at the protein level in EBV-infected carcinoma cells. This effect resulted from the ability of EBNA1 to repress TGFbeta1-induced transcription via a reduction in the interaction of SMAD2 with SMAD4. More detailed analysis revealed that EBNA1 induces a lower steady-state level of SMAD2 protein as a consequence of increased protein turnover. These data show that EBNA1 can influence cellular gene transcription resulting in effects that may contribute to the development of EBV-associated tumors.
PMID	17486072
GEOID	
AUTHORS	Wood VH,O'Neil JD,Wei W,Stewart SE,Dawson CW,Young LS
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	76P,ABI2,AGPS,AKR1C1,AKR1C2,AKR1C3,ALDH3A1,ANXA6,APOBEC3B,ARHGDIA,ASS,ATP5G3,BAG3,C1S,C3,CALM3,CCDC6,CD44,CHERP,CHN1,CLU,CTSC,CTSD,DGCR2,DNAJB1,DPAGT1,DUSP14,EEF1A2,EIF4G1,EMP2,EPHX1,F8A1,FASN,FBLN1,FBN2,FGFR3,FHL1,FZD2,GCLM,GLUL,GNAS,GSTM4,GTF3C3,H1FX,HIRA,HNRPA0,HNRPA3P1,HOXC10,HOXC6,HSPA1A,HSPA1B,HSPD1,HSPE1,HYOU1,ICAM1,ID2,IGF2R,ILF3,INHBC,INPP1,ITGAV,LGALS3BP,LGR5,MAML1,MAPRE2,MTX2,MYC,NAB1,NCKAP1,NEFH,NELL2,NFE2L2,NQO1,OPN3,P2RX5,PGD,PIR,PNMA1,PODXL,PRKCSH,PRKRA,PTBP1,RBPMS,S100A4,SCARB1,SERPINH1,SF1,SF3A2,SF3B1,SIX2,SKP2,SLC29A1,SLC29A2,SLCO3A1,SLCO4A1,SORD,SPON2,SRRM1,STAT1,TFAP2C,TMPRSS3,TRIM16,TUBA3,TXNRD1,TYRO3,UBE2E3,UCK2,UGDH,WASPIP,ZNF580
GENE_SYMBOLS	TUBGCP4,ABI2,AGPS,AKR1C1,AKR1C2,AKR1C3,ALDH3A1,ANXA6,APOBEC3B,ARHGDIA,ASS1,ATP5MC3,BAG3,C1S,C3,CALM3,CCDC6,CD44,CHERP,CHN1,CLU,CTSC,CTSD,DGCR2,DNAJB1,DPAGT1,DUSP14,EEF1A2,EIF4G1,EMP2,EPHX1,F8A1,FASN,FBLN1,FBN2,FGFR3,FHL1,FZD2,GCLM,GLUL,GNAS,GSTM4,GTF3C3,H1-10,HIRA,HNRNPA0,HNRNPA3P1,HOXC10,HOXC6,HSPA1A,HSPA1B,HSPD1,HSPE1,HYOU1,ICAM1,ID2,IGF2R,ILF3,INHBC,INPP1,ITGAV,LGALS3BP,LGR5,MAML1,MAPRE2,MTX2,MYC,NAB1,NCKAP1,NEFH,NELL2,NFE2L2,NQO1,OPN3,P2RX5,PGD,PIR,PNMA1,PODXL,PRKCSH,PRKRA,PTBP1,RBPMS,S100A4,SCARB1,SERPINH1,SF1,SF3A2,SF3B1,SIX2,SKP2,SLC29A1,SLC29A2,SLCO3A1,SLCO4A1,SORD,SPON2,SRRM1,STAT1,TFAP2C,TMPRSS3,TRIM16,TUBA1A,TXNRD1,TYRO3,UBE2E3,UCK2,UGDH,WIPF1,ZNF580
FOUNDER_NAMES