STANDARD_NAME	WOTTON_RUNX_TARGETS_UP
SYSTEMATIC_NAME	M11756
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WOTTON_RUNX_TARGETS_UP
NAMESPACE	AFFY_Mouse430
DESCRIPTION_BRIEF	Common target genes up-regulated by all three Runx family members (RUNX1, RUNX2, and RUNX3 [GeneID=861;860;864]) in MEF cells (embryonic fibroblasts).
DESCRIPTION_FULL	The Runx genes are important in development and cancer, where they can act either as oncogenes or tumour suppressors. We compared the effects of ectopic Runx expression in established fibroblasts, where all three genes produce an indistinguishable phenotype entailing epithelioid morphology and increased cell survival under stress conditions. Gene array analysis revealed a strongly overlapping transcriptional signature, with no examples of opposing regulation of the same target gene. A common set of 50 highly regulated genes was identified after further filtering on regulation by inducible RUNX1-ER. This set revealed a strong bias toward genes with annotated roles in cancer and development, and a preponderance of targets encoding extracellular or surface proteins, reflecting the marked effects of Runx on cell adhesion. Furthermore, in silico prediction of resistance to glucocorticoid growth inhibition was confirmed in fibroblasts and lymphoid cells expressing ectopic Runx. The effects of fibroblast expression of common RUNX1 fusion oncoproteins (RUNX1-ETO, TEL-RUNX1 and CBFB-MYH11) were also tested. Although two direct Runx activation target genes were repressed (Ncam1 and Rgc32), the fusion proteins appeared to disrupt the regulation of downregulated targets (Cebpd, Id2 and Rgs2) rather than impose constitutive repression. These results elucidate the oncogenic potential of the Runx family and reveal novel targets for therapeutic inhibition.
PMID	18560354
GEOID	GSE11732
AUTHORS	Wotton S,Terry A,Kilbey A,Jenkins A,Herzyk P,Cameron E,Neil JC
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1416414_at,1416612_at,1417061_at,1417130_s_at,1418003_at,1420380_at,1421228_at,1421269_at,1423405_at,1425985_s_at,1426315_a_at,1426865_a_at,1426968_a_at,1432478_a_at,1435639_at,1448145_at,1449151_at,1453304_s_at,1454877_at,1456195_x_at,1460241_a_at
GENE_SYMBOLS	KHK,CYP1B1,SLC40A1,ANGPTL4,RGCC,CCL2,CCL7,UGCG,TIMP4,MASP1,TMEM268,NCAM1,RDH10,RNF19B,GPR15LG,WWP2,CDK18,LY6E,SERTAD4,ITGB5,ST3GAL5
FOUNDER_NAMES