STANDARD_NAME	XU_CREBBP_TARGETS_UP
SYSTEMATIC_NAME	M17669
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/XU_CREBBP_TARGETS_UP
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes up-regulated in pro-B lymphocytes after knockout of CREBBP [GeneID=1387].
DESCRIPTION_FULL	CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice. CBP and p300 are generally considered limiting for transcription, yet their roles in adult cell lineages are largely unknown since homozygous null mutations in either gene or compound heterozygosity cause early embryonic lethality in mice. We tested the hypotheses that CBP and p300 are limiting and that each has unique properties in B cells, by using mice with Cre/LoxP conditional knockout alleles for CBP (CBP(flox)) and p300 (p300(flox)), which carry CD19(Cre) that initiates floxed gene recombination at the pro-B-cell stage. CD19(Cre)-mediated loss of CBP or p300 led to surprisingly modest deficits in B-cell numbers, whereas inactivation of both genes was not tolerated by peripheral B cells. There was a moderate decrease in B-cell receptor (BCR)-responsive gene expression in CBP or p300 homozygous null B cells, suggesting that CBP and p300 are essential for this signaling pathway that is crucial for B-cell homeostasis. These results indicate that individually CBP and p300 are partially limiting beyond the pro-B-cell stage and that other coactivators in B cells cannot replace their combined loss.
PMID	16424387
GEOID	
AUTHORS	Xu W,Fukuyama T,Ney PA,Wang D,Rehg J,Boyd K,van Deursen JM,Brindle PK
CONTRIBUTOR	Kevin Vogelsang
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100880_at,101366_f_at,102113_f_at,103518_at,103916_at,104722_at,160101_at,160473_at,160802_at,160896_at,161045_at,161985_f_at,162032_f_at,162337_f_at,92344_at,92770_at,92780_f_at,93112_at,93130_at,93261_at,93390_g_at,93861_f_at,94340_at,96696_at,97098_at,97282_at,97420_at,98948_at,98999_at,99005_at
GENE_SYMBOLS	GBP4,NVL,,,LDAF1,LMBR1L,HMOX1,NME4,PPAN,RCN1,LRRN1,,,,HLTF,S100A6,,MCM2,RRP1B,LGMN,PROM1,,XPOT,PRMT1,THA1P,,SEMA6B,GNL3,ADSL,RAD1
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