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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="XU_CREBBP_TARGETS_UP" SYSTEMATIC_NAME="M17669" HISTORICAL_NAMES="" PMID="16424387" AUTHORS="Xu W,Fukuyama T,Ney PA,Wang D,Rehg J,Boyd K,van Deursen JM,Brindle PK" GEOID="" EXACT_SOURCE="Table 1S" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_MG_U74" CONTRIBUTOR="Kevin Vogelsang" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in pro-B lymphocytes after knockout of CREBBP [GeneID=1387]." DESCRIPTION_FULL="CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice. CBP and p300 are generally considered limiting for transcription, yet their roles in adult cell lineages are largely unknown since homozygous null mutations in either gene or compound heterozygosity cause early embryonic lethality in mice. We tested the hypotheses that CBP and p300 are limiting and that each has unique properties in B cells, by using mice with Cre/LoxP conditional knockout alleles for CBP (CBP(flox)) and p300 (p300(flox)), which carry CD19(Cre) that initiates floxed gene recombination at the pro-B-cell stage. CD19(Cre)-mediated loss of CBP or p300 led to surprisingly modest deficits in B-cell numbers, whereas inactivation of both genes was not tolerated by peripheral B cells. There was a moderate decrease in B-cell receptor (BCR)-responsive gene expression in CBP or p300 homozygous null B cells, suggesting that CBP and p300 are essential for this signaling pathway that is crucial for B-cell homeostasis. These results indicate that individually CBP and p300 are partially limiting beyond the pro-B-cell stage and that other coactivators in B cells cannot replace their combined loss." TAGS="" MEMBERS="100880_at,101366_f_at,102113_f_at,103518_at,103916_at,104722_at,160101_at,160473_at,160802_at,160896_at,161045_at,161985_f_at,162032_f_at,162337_f_at,92344_at,92770_at,92780_f_at,93112_at,93130_at,93261_at,93390_g_at,93861_f_at,94340_at,96696_at,97098_at,97282_at,97420_at,98948_at,98999_at,99005_at" MEMBERS_SYMBOLIZED="ADSL,GBP4,GNL3,HLTF,HMOX1,LDAF1,LGMN,LMBR1L,LRG1,LRRN1,MCM2,NME4,NVL,PPAN,PRMT1,PROM1,RAD1,RCN1,RRP1B,S100A6,THA1P,XPOT" MEMBERS_EZID="11260,115361,116844,158,23076,26354,3162,3276,390816,4171,4833,4931,55716,56342,5641,57146,57633,5810,5954,6277,6596,8842" MEMBERS_MAPPING="100880_at,GBP4,115361|101366_f_at,NVL,4931|102113_f_at,null,null|103518_at,null,null|103916_at,LDAF1,57146|104722_at,LMBR1L,55716|160101_at,HMOX1,3162|160473_at,NME4,4833|160802_at,PPAN,56342|160896_at,RCN1,5954|161045_at,LRRN1,57633|161985_f_at,null,null|162032_f_at,null,null|162337_f_at,null,null|92344_at,HLTF,6596|92770_at,S100A6,6277|92780_f_at,null,null|93112_at,MCM2,4171|93130_at,RRP1B,23076|93261_at,LGMN,5641|93390_g_at,PROM1,8842|93861_f_at,null,null|94340_at,XPOT,11260|96696_at,PRMT1,3276|97098_at,THA1P,390816|97282_at,null,null|97420_at,LRG1,116844|98948_at,GNL3,26354|98999_at,ADSL,158|99005_at,RAD1,5810" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
