STANDARD_NAME YAGI_AML_FAB_MARKERS SYSTEMATIC_NAME M5103 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAGI_AML_FAB_MARKERS NAMESPACE AFFY_HG_U95 DESCRIPTION_BRIEF Genes specifically expressed in FAB subtypes M2, M4, M5 and M7 of pediatric AML (acute myeloid leukemia). DESCRIPTION_FULL Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients. PMID 12738660 GEOID GSE2191 AUTHORS Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H CONTRIBUTOR Kevin Vogelsang CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1035_g_at,1038_s_at,1054_at,1105_s_at,1375_s_at,1460_g_at,1506_at,1583_at,1633_g_at,1641_s_at,174_s_at,1884_s_at,1892_s_at,203_at,262_at,31797_at,31805_at,31880_at,32206_at,32249_at,32250_at,32617_at,32663_at,32805_at,32827_at,33063_at,33227_at,33252_at,33355_at,33390_at,33411_g_at,33412_at,33421_s_at,33598_r_at,33791_at,33813_at,33821_at,33894_at,34280_at,34339_at,34356_at,34376_at,34412_s_at,34517_at,34673_r_at,34714_at,34764_at,34792_at,34795_at,34819_at,34916_s_at,35101_at,35160_at,35172_at,35177_at,35218_at,35291_at,35318_at,35364_at,35481_at,35627_at,35628_at,35638_at,35640_at,35724_at,35752_s_at,35756_at,35771_at,35800_at,35839_at,35869_at,35939_s_at,35940_at,36028_at,36088_at,36119_at,36142_at,36189_at,36192_at,36269_at,36313_at,36365_at,36464_at,36491_at,36561_at,36601_at,36655_at,36658_at,36708_at,36709_at,36741_at,36792_at,36805_s_at,36851_g_at,36879_at,36941_at,36957_at,37001_at,37011_at,37015_at,37023_at,37027_at,37177_at,37183_at,37259_at,37263_at,37470_at,37472_at,37493_at,37534_at,37610_at,37623_at,37647_at,37678_at,37716_at,37747_at,37809_at,37811_at,37883_i_at,37892_at,37951_at,37952_at,38107_at,38197_at,38391_at,38404_at,38411_at,38453_at,38454_g_at,38620_at,38631_at,38805_at,38997_at,38998_g_at,39076_s_at,39123_s_at,39167_r_at,39269_at,39320_at,39338_at,39372_at,39373_at,39425_at,39519_at,39581_at,39600_at,39613_at,39681_at,39717_g_at,39748_at,39776_at,39794_at,39997_at,40000_f_at,40002_r_at,40016_g_at,40024_at,40043_at,40045_g_at,40062_s_at,40077_at,40113_at,40127_at,40229_at,40244_s_at,40335_at,40401_at,40495_at,40564_at,40606_at,40643_at,40644_g_at,40662_g_at,40687_at,40715_at,40718_at,40844_at,40861_at,40877_s_at,40878_f_at,40900_at,40943_at,41028_at,41188_at,41246_at,41257_at,41289_at,41474_at,41549_s_at,41574_at,41610_at,41645_at,41690_at,41700_at,41718_g_at,41719_i_at,41720_r_at,41767_r_at,41790_at,422_s_at,546_at,547_s_at,574_s_at,590_at,633_s_at,717_at,743_at,769_s_at,808_at,842_at,906_at,925_at,933_f_at GENE_SYMBOLS TIMP3,IFNGR1,RFC4,TRBC2,TIMP2,PTPN4,IL2RG,TNFRSF1B,PIM2,DDB1,ITSN2,PCNA,NTRK1,GATA2,AMD1,TBPL1,FGFR3,UBXN8,CDC42BPA,CFH,CFH,FANCI,RHAG,AKR1C1,RRAS2,GP1BA,IL10RB,MCM3,PBX1,CD68,ITGA6,LGALS1,SC5D,NLRP3,DLEU1,TNFRSF1B,ELOVL5,NET1,GABRE,CYB5B,MED21,PKIG,GP1BB,HMGCS1,HDGFL3,SAMHD1,LARS2,AHCYL1,PLOD2,CD164,TNFRSF4,GP9,LDB1,TPST2,DDHD2,PDCD10,BAG2,FAM20B,NAE1,MYO16,SNTA1,TM7SF2,RUNX1T1,RUNX1T1,PIR,PROS1,GIPC1,DEAF1,PAFAH1B3,SQLE,LY86,POU4F1,POU4F1,TCIRG1,PSMG1,CAV1,ATXN1,ILF2,SCRN1,ADAMTS3,EVI2A,TRPC6,CRISP3,TMSB15A,PCCB,VCL,TJP2,DHCR24,CPM,ITGAX,GIT2,TPM1,NTRK1,TUSC3,TYMP,MLLT11,ZMYND8,CAPN2,AIF1,ALDH1A1,LCP1,AHNAK,CD58,GAD1,SERPINI1,GGH,LAIR1,MANBA,CSF2RB,CXADR,COA1,NR4A2,AOAH,BAMBI,CD200,ANXA5,HOXA9,CACNA2D2,C2orf27A,COL11A1,DLC1,ITGB3,UNC119,KEL,CAPG,TGM2,SORL1,ICAM2,ICAM2,GOSR2,TNFAIP2,TGIF1,,SLC25A1,DRAP1,TRPC1,SERPINH1,RFC3,CASP1,S100A10,FADS1,FADS1,TXNRD1,ANKLE2,CSTA,PAQR3,MAN1A1,ZBTB16,MRPL33,SLC7A1,ULK2,USP8,CFP,VPS13A,,MAST4,STAC,PRSS3,LDLRAD4,MYL4,ACO1,TRIB2,SFXN3,TOM1L1,MPPE1,CLCN4,DOK5,ORAI2,NUP50,ELL2,ITGA2B,ITGA2B,NR4A3,GJA4,CD180,CTSW,CTR9,MORF4L2,HERC2P9,,MYH10,ELOVL6,RYR3,LAPTM4B,SERPINE2,CAST,NCAM1,KIF2A,AP1S2,PNN,LAMA5,PLA2G6,ARID5B,F2R,FADS1,FADS1,FADS1,GOLGA8A,ALDH5A1,MAX,PKIA,NR4A2,CASP1,ICAM2,TFDP2,TRIB2,NAP1L3,ANXA2,RAB27B,ZMYND8,STAT4,IFI30,ZNF91 FOUNDER_NAMES