STANDARD_NAME	YAGI_AML_RELAPSE_PROGNOSIS
SYSTEMATIC_NAME	M15262
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAGI_AML_RELAPSE_PROGNOSIS
NAMESPACE	AFFY_HG_U95
DESCRIPTION_BRIEF	Genes associated with clinical prognosis of pediatric AML (acute myeloid leukemia): good prognosis=no relapse > 3 years; poor prognosis=relapse < 1 year or no response to therapy.
DESCRIPTION_FULL	Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.
PMID	12738660
GEOID	GSE2191
AUTHORS	Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H
CONTRIBUTOR	Kate Stafford
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1207_at,1241_at,1461_at,1985_s_at,288_s_at,32675_at,32806_at,33390_at,33683_at,33944_at,33963_at,34905_at,35536_at,35631_at,36167_at,36338_at,36661_s_at,36879_at,36958_at,36963_at,37298_at,37729_at,38016_at,38233_at,38614_s_at,38628_at,38789_at,39011_at,39345_at,39353_at,40147_at,40198_at,41396_at,41523_at,41763_g_at,605_at
GENE_SYMBOLS	CDK6,PTP4A2,NFKBIA,NME1,LBR,BST1,TSPO,CD68,TUG1,APLP2,AZU1,GRIK5,ECE2,POLR2H,ATP6V0B,LUZP1,CD14,TYMP,ZYX,PGD,GABARAP,XPO1,HNRNPD,HOMER3,OGT,KAT2A,TKT,ENSA,NPC2,HSPE1,VAT1,VDAC1,CLIP2,RAB32,TIAL1,VAT1
FOUNDER_NAMES