STANDARD_NAME YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 SYSTEMATIC_NAME M15699 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 NAMESPACE AFFY_MG_U74 DESCRIPTION_BRIEF Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 0. DESCRIPTION_FULL Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus. PMID 12554760 GEOID GSE106,GSE107 AUTHORS Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Supp. data: out_b_data Web S6: Cluster No.=0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100153_at,100309_at,100944_at,101587_at,101853_f_at,101889_s_at,101923_at,101998_at,102235_at,102370_at,102881_at,102905_at,103222_at,103556_at,103574_at,103697_at,103736_at,103804_at,103916_at,103944_at,104011_at,104252_at,104415_at,104445_at,104449_at,104513_at,104603_at,104607_at,104725_at,104728_at,160095_at,160117_at,160138_at,160287_at,160288_at,160522_at,160546_at,160611_at,160655_at,160827_at,160841_at,160894_at,161005_at,161177_f_at,161342_r_at,161354_f_at,161616_f_at,162161_r_at,162258_f_at,92534_at,92759_at,93011_at,93142_at,93178_at,93188_at,93191_at,93193_at,93202_at,93390_g_at,93500_at,93836_at,93907_f_at,93908_f_at,93909_f_at,93965_r_at,94120_s_at,94354_at,94432_at,94872_at,95083_at,95731_at,96348_at,96494_at,96615_at,96728_at,97181_f_at,97198_at,97224_at,97317_at,97336_at,97391_at,97730_at,97790_s_at,98254_f_at,98369_f_at,98472_at,98478_at,98507_at,98855_r_at,99076_at,99481_at,99498_at GENE_SYMBOLS NCAM1,MET,,EPHX1,CFH,RORA,PLA2G7,C5orf34,MYCL,HSD17B11,BBS9,CASP4,EPS8,ANGPTL2,ABLIM1,LIFR,SASH1,RECK,LDAF1,RAD51B,AOX1,,FOXP1,ITIH5,GLRB,,GSTT2,RTN2,RHOQ,PROS1,LOX,TEF,MXI1,MAP1LC3B2,MAP1LC3B2,NREP,ALDOC,CYP4V2,CPD,RIN2,DBP,CEBPD,TXNDC16,,,,,,,GEM,LAMB3,GABARAPL1,BACH1,NGEF,DKK3,VAMP4,ADRB2,NT5E,PROM1,ALAS1,BNIP3,,,,DDX6,,ABCA1,ST6GAL1,SMPDL3A,IGFBP3,SESN1,PNPLA2,KLHL24,YPEL3,WDR45,,ABCA1,,ENPP2,CTSF,HAUS4,ABCA4,LAMA3,,,HLA-E,CCNG2,NR1D1,CREBRF,NR1D2,ATP1A2, FOUNDER_NAMES