STANDARD_NAME YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 SYSTEMATIC_NAME M1033 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 NAMESPACE AFFY_MG_U74 DESCRIPTION_BRIEF Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 10. DESCRIPTION_FULL Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus. PMID 12554760 GEOID GSE106,GSE107 AUTHORS Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Supp. data: out_b_data Web S6: Cluster No.=10 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100523_r_at,100943_at,100984_at,101065_at,101091_at,101524_at,101703_at,101869_s_at,102302_at,103018_at,103047_at,103534_at,103726_at,103853_at,104279_at,104565_at,104573_at,160180_at,160217_at,160230_at,160291_at,160385_at,160396_at,160447_at,160513_at,160529_r_at,160562_at,160569_at,161135_f_at,162457_f_at,92565_at,92579_at,92596_at,92809_r_at,92829_at,92850_at,93512_f_at,93533_at,93551_at,93603_at,93817_at,93819_at,94077_f_at,94389_at,94452_g_at,94470_i_at,94491_at,94512_f_at,94781_at,94931_at,94998_at,95058_f_at,95069_at,95086_at,95441_at,95679_at,95708_at,96008_at,96029_at,96072_at,96276_r_at,96298_f_at,96322_at,96676_at,96883_at,97124_at,97308_at,97459_at,97491_at,97526_at,97758_at,98603_s_at,98837_at,98953_at,99153_at,99546_at,99561_f_at GENE_SYMBOLS TCEAL9,SLC1A4,ATF1,PCNA,SUMO1,HNRNPA3,,HBB,BCKDHB,USO1,PEX2,,YIPF5,GRWD1,POLR2F,AP4S1,BOLA2,CANX,APMAP,COX17,SEC61A1,GCSH,CERS2,MFSD14A,C9orf64,VDAC2,CCT7,OSTC,,,SARNP,SSB,CACYBP,FKBP4,HSPE1,RRBP1,ADK,SSU72,POLR2L,MRPL40,,TMED2,RPN2,,NSUN2,SLC30A5,PEX13,ARCN1,,UFM1,RALA,MPC2,SSRP1,TRIR,TIMM23,CDK2AP2,SERP1,DAD1,SF3A3,LDHA,TM9SF3,DYNLL1,EDF1,CHCHD7,EIF3G,GSDME,TMEM11,PSMA4,HNRNPR,AP3M1,PRDX1,RANGAP1,RLN1,EIF1B,MRPL53,FKBP2,CLDN7 FOUNDER_NAMES