STANDARD_NAME	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_3
SYSTEMATIC_NAME	M12322
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_3
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 3.
DESCRIPTION_FULL	Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.
PMID	12554760
GEOID	GSE106,GSE107
AUTHORS	Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Supp. data: out_b_data Web S6: Cluster No.=3
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100360_f_at,100362_f_at,100376_f_at,100377_f_at,100583_at,100682_f_at,100721_f_at,101319_f_at,101320_f_at,101326_at,101331_f_at,101633_at,101656_f_at,101720_f_at,101743_f_at,101747_f_at,101752_f_at,102154_f_at,102156_f_at,102157_f_at,102225_at,102292_at,102372_at,102585_f_at,104149_at,160614_at,92295_at,92356_at,92470_f_at,92642_at,92779_f_at,93086_at,93227_f_at,93351_at,93904_f_at,93927_f_at,93945_at,94352_at,96963_s_at,96970_at,96973_f_at,96975_at,97563_f_at,97564_f_at,97574_f_at,97576_f_at,97577_f_at,98014_at,99405_at,99420_at,99640_at
GENE_SYMBOLS	IGHV1-69-2,IGHV1-69-2,IGHV1-69,IGHV1-18,IGHA2,,IGHV1-69,,,IGHV2-26,IGKV4-1,IGKV5-2,IGKV2D-29,IGKV4-1,,,,IGKV4-1,,IGLV1-50,RABGAP1L,GADD45A,JCHAIN,IGLV2-18,NFKBIA,PTEN,SEMA3E,PTPN22,IGHV1-69,CA2,,IGKC,IGKV4-1,HPGD,IGHV1-24,IGHV1-18,ESR1,MBTD1,IGKV4-1,,IGHV1-18,,IGHV1-69,IGKV2D-29,IGHV1-18,,,ITIH1,IGKV2D-30,,MINPP1
FOUNDER_NAMES