STANDARD_NAME	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4
SYSTEMATIC_NAME	M16325
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 4.
DESCRIPTION_FULL	Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.
PMID	12554760
GEOID	GSE106,GSE107
AUTHORS	Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Supp. data: out_b_data Web S6: Cluster No.=4
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100295_at,101141_at,102613_at,103294_at,103873_i_at,104440_at,160424_f_at,160628_at,160832_at,161487_f_at,162295_at,162402_r_at,92429_at,92514_at,95514_at,97372_at,97755_at,99082_at,99098_at,99397_at,99430_at,99531_at,99959_at
GENE_SYMBOLS	IGLV4-69,,,RGS5,CCDC90B,YBX2,FDPS,GCAT,LDLR,,,,MC2R,BARX1,RCC2,,DRD4,FKBP10,FDPS,ERCC2,GALR2,SYNGR4,AK4
FOUNDER_NAMES