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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4" SYSTEMATIC_NAME="M16325" HISTORICAL_NAMES="" PMID="12554760" AUTHORS="Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL" GEOID="GSE106,GSE107" EXACT_SOURCE="Supp. data: out_b_data Web S6: Cluster No.=4" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_MG_U74" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 4." DESCRIPTION_FULL="Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus." TAGS="" MEMBERS="100295_at,101141_at,102613_at,103294_at,103873_i_at,104440_at,160424_f_at,160628_at,160832_at,161487_f_at,162295_at,162402_r_at,92429_at,92514_at,95514_at,97372_at,97755_at,99082_at,99098_at,99397_at,99430_at,99531_at,99959_at" MEMBERS_SYMBOLIZED="AK4,BARX1,CCDC90B,DRD4,ERCC2,FDPS,FKBP10,GALR2,GCAT,IGLV4-69,LDLR,MC2R,RCC2,RGS5,SYNGR4,YBX2" MEMBERS_EZID="1815,205,2068,2224,23464,23546,28784,3949,4158,51087,55920,56033,60492,60681,8490,8811" MEMBERS_MAPPING="100295_at,IGLV4-69,28784|101141_at,null,null|102613_at,null,null|103294_at,RGS5,8490|103873_i_at,CCDC90B,60492|104440_at,YBX2,51087|160424_f_at,FDPS,2224|160628_at,GCAT,23464|160832_at,LDLR,3949|161487_f_at,null,null|162295_at,null,null|162402_r_at,null,null|92429_at,MC2R,4158|92514_at,BARX1,56033|95514_at,RCC2,55920|97372_at,null,null|97755_at,DRD4,1815|99082_at,FKBP10,60681|99098_at,FDPS,2224|99397_at,ERCC2,2068|99430_at,GALR2,8811|99531_at,SYNGR4,23546|99959_at,AK4,205" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
