STANDARD_NAME YIH_RESPONSE_TO_ARSENITE_C5 SYSTEMATIC_NAME M2023 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YIH_RESPONSE_TO_ARSENITE_C5 NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes in cluster 5: slowly down-regulated in HFW cells (fibroblast) by sodium arsenite [PubChem=26435]. DESCRIPTION_FULL Arsenic compounds are widely distributed and arsenic ingestion is associated with many human diseases, including blackfoot disease, atherosclerosis, and cancers. However, the underlying mechanism of arsenic toxicity is not understood. In human fibroblast cells (HFW), arsenite is known to induce oxidative damage, chromosome aberrations, cell cycle arrest, and aneuploidy, and the manifestation of these cellular responses is dependent on changes in gene expression which can be analyzed using the cDNA microarray technique. In this study, cDNA microarray membranes with 568 human genes were used to examine mRNA profile changes in HFW cells treated for 0 to 24 h with 5 microM sodium arsenite. On the basis of the mean value for three independent experiments, 133 target genes were selected for a 2 x 3 self-organizing map cluster analysis; 94 were found to be induced by arsenite treatment, whereas 39 were repressed. These genes were categorized as signal transduction, transcriptional regulation, cell cycle control, stress responses, proteolytic enzymes, and miscellaneous. Significant changes in the signaling-related and transcriptional regulation genes indicated that arsenite induces complex toxicopathological injury. PMID 12016162 GEOID AUTHORS Yih LH,Peck K,Lee TC CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1: Cluster 5 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS H14638,H18877,H44233,H50710,R55296,R63773,R73533,R74194,R76562,T77817,T87872 GENE_SYMBOLS ACKR1,L1CAM,CRABP2,KRT15,PML,PGF,TNFAIP6,PLAU,KRT19,CCL2,MAP2K1 FOUNDER_NAMES