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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="ZHENG_IL22_SIGNALING_UP" SYSTEMATIC_NAME="M1800" HISTORICAL_NAMES="" PMID="18264109" AUTHORS="Zheng Y,Valdez PA,Danilenko DM,Hu Y,Sa SM,Gong Q,Abbas AR,Modrusan Z,Ghilardi N,de Sauvage FJ,Ouyang W" GEOID="GSE10010" EXACT_SOURCE="Table 1S" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="MOUSE_SEQ_ACCESSION" CONTRIBUTOR="Jessica Robertson" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in ex-vivo colonic tissue after treatment with IL22 [GeneID=50616]." DESCRIPTION_FULL="Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter rodentium, we show that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C. rodentium. Infection of IL-22 knockout mice results in increased intestinal epithelial damage, systemic bacterial burden and mortality. We also find that IL-23 is required for the early induction of IL-22 during C. rodentium infection, and adaptive immunity is not essential for the protective role of IL-22 in this model. Instead, IL-22 is required for the direct induction of the Reg family of antimicrobial proteins, including RegIIIbeta and RegIIIgamma, in colonic epithelial cells. Exogenous mouse or human RegIIIgamma substantially improves survival of IL-22 knockout mice after C. rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens." TAGS="" MEMBERS="AK009488,AK011413,AK032717,AK034993,AK052629,AK075639,AK087113,AK172918,AK173296,BC033508,BC046640,BC089618,D86599,NM_001001332,NM_007482,NM_007646,NM_007969,NM_008198,NM_008218,NM_008220,NM_008380,NM_008872,NM_008987,NM_009114,NM_009141,NM_009311,NM_009378,NM_009684,NM_009778,NM_009841,NM_009886,NM_010741,NM_011036,NM_011095,NM_011315,NM_011409,NM_011414,NM_011472,NM_011593,NM_013459,NM_013505,NM_013515,NM_013650,NM_013653,NM_016674,NM_017370,NM_019932,NM_019984,NM_020509,NM_021443,NM_021457,NM_021792,NM_025549,NM_026232,NM_026835,NM_027406,NM_027893,NM_028113,NM_028618,NM_029662,NM_029796,NM_030061,NM_031188,NM_133232,NM_133775,NM_138648,NM_145133,NM_145555,NM_153457,NM_172440,NM_172796,NM_177314,NM_181542,NM_183426,NM_203320,XM_485455,XM_894811,XM_899837,XM_905096" MEMBERS_SYMBOLIZED="ALDH1L1,AMER2,APAF1,ARG1,ARRDC4,C3,CCL5,CCL8,CD14,CD38,CELSR1,CFB,CFD,CLDN1,CSTA,CXCL6,DMKN,DSC2,FREM1,FZD1,HBA2,HBB,HP,IL33,INHBA,LILRB1,LRG1,MFSD2A,MS4A6A,NCMAP,NECTIN4,OLR1,OXTR,PF4,PFKFB3,PLAT,PTX3,REG3A,RETNLB,RTN1,S100A8,S100A9,SBNO2,SLC25A30,SLFN12,SLFN13,SLITRK1,SLPI,SPINK9,STING1,STOM,STXBP5L,TAC1,TGM1,THBD,TIFA,TIMP1,TTC9" MEMBERS_EZID="10840,10859,114798,116844,146857,1475,158326,1675,1824,2040,219287,22904,23508,253512,3040,3043,317,3240,340061,3624,383,400746,4973,5021,5068,5196,5209,5327,55106,5806,6252,6279,6280,629,6352,6355,6372,64231,643394,6590,6863,7051,7056,7076,718,81607,8321,84666,84879,9076,90865,91947,92610,929,93099,9515,952,9620" MEMBERS_MAPPING="AK009488,null,null|AK011413,null,null|AK032717,null,null|AK034993,null,null|AK052629,FREM1,158326|AK075639,null,null|AK087113,null,null|AK172918,TTC9,23508|AK173296,SLITRK1,114798|BC033508,CCL5,6352|BC046640,STING1,340061|BC089618,null,null|D86599,OXTR,5021|NM_001001332,CSTA,1475|NM_007482,ARG1,383|NM_007646,CD38,952|NM_007969,null,null|NM_008198,CFB,629|NM_008218,HBA2,3040|NM_008220,HBB,3043|NM_008380,INHBA,3624|NM_008872,PLAT,5327|NM_008987,PTX3,5806|NM_009114,S100A9,6280|NM_009141,CXCL6,6372|NM_009311,TAC1,6863|NM_009378,THBD,7056|NM_009684,APAF1,317|NM_009778,C3,718|NM_009841,CD14,929|NM_009886,CELSR1,9620|NM_010741,null,null|NM_011036,REG3A,5068|NM_011095,LILRB1,10859|NM_011315,null,null|NM_011409,SLFN12,55106|NM_011414,SLPI,6590|NM_011472,null,null|NM_011593,TIMP1,7076|NM_013459,CFD,1675|NM_013505,DSC2,1824|NM_013515,STOM,2040|NM_013650,S100A8,6279|NM_013653,CCL5,6352|NM_016674,CLDN1,9076|NM_017370,HP,3240|NM_019932,PF4,5196|NM_019984,TGM1,7051|NM_020509,RETNLB,84666|NM_021443,CCL8,6355|NM_021457,FZD1,8321|NM_021792,null,null|NM_025549,ARRDC4,91947|NM_026232,SLC25A30,253512|NM_026835,MS4A6A,64231|NM_027406,ALDH1L1,10840|NM_027893,NECTIN4,81607|NM_028113,AMER2,219287|NM_028618,DMKN,93099|NM_029662,MFSD2A,84879|NM_029796,LRG1,116844|NM_030061,SPINK9,643394|NM_031188,null,null|NM_133232,PFKFB3,5209|NM_133775,IL33,90865|NM_138648,OLR1,4973|NM_145133,TIFA,92610|NM_145555,NCMAP,400746|NM_153457,RTN1,6252|NM_172440,STXBP5L,9515|NM_172796,SLFN13,146857|NM_177314,null,null|NM_181542,SLFN13,146857|NM_183426,SBNO2,22904|NM_203320,null,null|XM_485455,null,null|XM_894811,null,null|XM_899837,null,null|XM_905096,null,null" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
