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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="ZUCCHI_METASTASIS_DN" SYSTEMATIC_NAME="M16826" HISTORICAL_NAMES="" PMID="15608061" AUTHORS="Zucchi I,Mento E,Kuznetsov VA,Scotti M,Valsecchi V,Simionati B,Vicinanza E,Valle G,Pilotti S,Reinbold R,Vezzoni P,Albertini A,Dulbecco R" GEOID="" EXACT_SOURCE="Table 1" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="UniGene_ID" CONTRIBUTOR="Kate Stafford" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="The 50 most down-regulated genes in primary invasive breast dutcal carcinoma (IDC) or lymph node metastases,  compared to normal mammary epithelium." DESCRIPTION_FULL="Expression profiles of breast carcinomas are difficult to interpret when they are obtained from tissue in toto, which may contain a large proportion of non-cancer cells. To avoid this problem, we microscopically isolated cells from a primary invasive ductal carcinoma of the breast and from an axillary node harboring a metastatic breast carcinoma, to obtain pure populations of carcinoma cells ( approximately 500) and used them for serial analysis of gene expression. The expression profiles generated from both populations of cells were compared with the profile of a disease-free mammary epithelium. We showed that the expression profiles obtained are exclusive of carcinoma cells with no contribution of non-epithelial cells. From a total of 16,939 unique tags analyzed, we detected 559 statistically significant changes in gene expression; some of these genes have not been previously associated with breast cancer. We observed that many of the down-regulated genes are the same in both cancers, whereas the up-regulated genes are completely different, suggesting that the down-regulation of a set of genes may be the basic mechanism of cancer formation, while the up-regulation may characterize and possibly control the state of evolution of individual cancers. The results obtained may help in characterizing the neoplastic process of breast cancer." TAGS="" MEMBERS="Hs.106674,Hs.110571,Hs.129673,Hs.14376,Hs.150580,Hs.164021,Hs.17883,Hs.191887,Hs.204096,Hs.2250,Hs.23582,Hs.23881,Hs.25829,Hs.270833,Hs.2780,Hs.279806,Hs.28081,Hs.28491,Hs.287558,Hs.288094,Hs.290758,Hs.304682,Hs.348419,Hs.351316,Hs.356285,Hs.377199,Hs.379039,Hs.384944,Hs.39252,Hs.400124,Hs.406918,Hs.408943,Hs.411701,Hs.432677,Hs.436441,Hs.443831,Hs.512234,Hs.5372,Hs.624,Hs.75498,Hs.75765,Hs.75807,Hs.75873,Hs.75969,Hs.77273,Hs.789,Hs.79474,Hs.81328,Hs.82222,Hs.89690" MEMBERS_SYMBOLIZED="" MEMBERS_EZID="" MEMBERS_MAPPING="Hs.106674,null,null|Hs.110571,null,null|Hs.129673,null,null|Hs.14376,null,null|Hs.150580,null,null|Hs.164021,null,null|Hs.17883,null,null|Hs.191887,null,null|Hs.204096,null,null|Hs.2250,null,null|Hs.23582,null,null|Hs.23881,null,null|Hs.25829,null,null|Hs.270833,null,null|Hs.2780,null,null|Hs.279806,null,null|Hs.28081,null,null|Hs.28491,null,null|Hs.287558,null,null|Hs.288094,null,null|Hs.290758,null,null|Hs.304682,null,null|Hs.348419,null,null|Hs.351316,null,null|Hs.356285,null,null|Hs.377199,null,null|Hs.379039,null,null|Hs.384944,null,null|Hs.39252,null,null|Hs.400124,null,null|Hs.406918,null,null|Hs.408943,null,null|Hs.411701,null,null|Hs.432677,null,null|Hs.436441,null,null|Hs.443831,null,null|Hs.512234,null,null|Hs.5372,null,null|Hs.624,null,null|Hs.75498,null,null|Hs.75765,null,null|Hs.75807,null,null|Hs.75873,null,null|Hs.75969,null,null|Hs.77273,null,null|Hs.789,null,null|Hs.79474,null,null|Hs.81328,null,null|Hs.82222,null,null|Hs.89690,null,null" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="ARCHIVED" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="C2_CGP"/>
</MSIGDB>
