STANDARD_NAME	ZUCCHI_METASTASIS_UP
SYSTEMATIC_NAME	M14951
COLLECTION	ARCHIVED:C2_CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/ZUCCHI_METASTASIS_UP
NAMESPACE	UniGene_ID
DESCRIPTION_BRIEF	The 50 most up-regulated genes in primary invasive breast dutcal carcinoma (IDC) or lymph node metastases,  compared to normal mammary epithelium.
DESCRIPTION_FULL	Expression profiles of breast carcinomas are difficult to interpret when they are obtained from tissue in toto, which may contain a large proportion of non-cancer cells. To avoid this problem, we microscopically isolated cells from a primary invasive ductal carcinoma of the breast and from an axillary node harboring a metastatic breast carcinoma, to obtain pure populations of carcinoma cells ( approximately 500) and used them for serial analysis of gene expression. The expression profiles generated from both populations of cells were compared with the profile of a disease-free mammary epithelium. We showed that the expression profiles obtained are exclusive of carcinoma cells with no contribution of non-epithelial cells. From a total of 16,939 unique tags analyzed, we detected 559 statistically significant changes in gene expression; some of these genes have not been previously associated with breast cancer. We observed that many of the down-regulated genes are the same in both cancers, whereas the up-regulated genes are completely different, suggesting that the down-regulation of a set of genes may be the basic mechanism of cancer formation, while the up-regulation may characterize and possibly control the state of evolution of individual cancers. The results obtained may help in characterizing the neoplastic process of breast cancer.
PMID	15608061
GEOID	
AUTHORS	Zucchi I,Mento E,Kuznetsov VA,Scotti M,Valsecchi V,Simionati B,Vicinanza E,Valle G,Pilotti S,Reinbold R,Vezzoni P,Albertini A,Dulbecco R
CONTRIBUTOR	Kate Stafford
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	Hs.104125,Hs.112208,Hs.118400,Hs.118638,Hs.119192,Hs.136227,Hs.1407,Hs.1516,Hs.1600,Hs.164969,Hs.170009,Hs.180414,Hs.183803,Hs.2110,Hs.24948,Hs.26663,Hs.26704,Hs.2795,Hs.296244,Hs.320147,Hs.32748,Hs.356331,Hs.364345,Hs.374524,Hs.374596,Hs.374650,Hs.386834,Hs.388004,Hs.406532,Hs.410037,Hs.412416,Hs.418004,Hs.418138,Hs.425801,Hs.433455,Hs.434102,Hs.448540,Hs.459927,Hs.476302,Hs.511956,Hs.525899,Hs.5308,Hs.5662,Hs.57301,Hs.61635,Hs.6891,Hs.7943,Hs.83381,Hs.85137,Hs.99932
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FOUNDER_NAMES