Standard name |
ABBUD_LIF_SIGNALING_2_UP |
Systematic name |
M1439 |
Brief description |
Genes up-regulated in GH3 cells (pituitary cancer) after treatment with LIF [GeneID=3976]. |
Full description or abstract |
Leukemia inhibitory factor (LIF) mediates the hypothalamo-pituitary-adrenal stress response. Transgenic mice overexpressing LIF in the developing pituitary have altered pituitary differentiation with expansion of corticotropes, maintenance of Rathke's cleft cysts, and suppression of all other pituitary cell types. Affymetrix GeneChips were used to identify modulators of LIF effects in corticotrope (AtT-20) and somatolactotrope (GH(3)) cells. In addition to genes known to respond to LIF in corticotrope cells [e.g. suppressor of cytokine signaling-3 (SOCS-3), signal transducer and activator of transcription-3, SH2 domain-containing tyrosine phosphatase-1, and proopiomelanocortin (POMC)], corticotrope-specific changes were also observed for genes involved in glycolysis and gluconeogenesis, transcription factors, signaling molecules, and expressed sequence tags. Two transcription factors identified, CCAAT/enhancer-binding protein beta (C/EBPbeta) and glial cell-derived neurotrophic factor (GDNF)-inducible factor (GIF), dose-dependently induced expression of the rat POMC promoter when overexpressed in AtT-20 cells. LIF further induced POMC transcription with C/EBPbeta, but not with GIF. C/EBPbeta also induced expression of the SOCS-3 promoter that was further enhanced by cotreatment with LIF. However, GIF did not affect SOCS-3 expression. These results indicate that C/EBPbeta and GIF are downstream effectors of LIF corticotrope action. LIF also stimulates the expression of inhibitors of its actions, such as SOCS-3 and SH2 domain-containing tyrosine phosphatase-1. alpha(2)-HS-glycoprotein (AHSG)/fetuin, a secreted protein that antagonizes bone TGFbeta/bone morphogenic protein signaling, was induced by LIF in a signal transducer and activator of transcription-3-dependent fashion. Pretreatment with AHSG/fetuin blocked LIF-induced expression of the POMC promoter independently of SOCS-3. Thus, using GeneChips, C/EBPbeta and GIF have been identified as novel mediators and AHSG/fetuin as an inhibitor of LIF action in corticotropes. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 14576184 Authors: Abbud RA,Kelleher R,Melmed S |
Exact source |
Table 3 |
Related gene sets |
(show 3 additional gene sets from the source publication)
(show 1 gene sets from the same authors)
|
External links |
|
Filtered by similarity ?
|
|
Source species |
Rattus norvegicus |
Contributed by |
Kevin Vogelsang (MSigDB Team) |
Source platform or identifier namespace |
RAT_SEQ_ACCESSION |
Dataset references |
|
Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
|
Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
|
Advanced query |
Further investigate
these 13 genes
|
Gene families ? |
Categorize these
13 genes by gene family
|
Show members |
(show 17 source identifiers mapped to 13 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AA800587 |
2877 |
GPX2 |
glutathione peroxidase 2 [Source:HGNC Symbo... |
AA875197 |
|
|
|
AA891041 |
3726 |
JUNB |
JunB proto-oncogene, AP-1 transcription fac... |
AF016296 |
8829 |
NRP1 |
neuropilin 1 [Source:HGNC Symbol;Acc:HGNC:8... |
AI103238 |
5521 |
PPP2R2B |
protein phosphatase 2 regulatory subunit Bb... |
AI230614 |
481 |
ATP1B1 |
ATPase Na+/K+ transporting subunit beta 1 [... |
AI639162 |
|
|
|
AJ005396 |
1301 |
COL11A1 |
collagen type XI alpha 1 chain [Source:HGNC... |
L25387 |
5214 |
PFKP |
phosphofructokinase, platelet [Source:HGNC ... |
S54008 |
2260 |
FGFR1 |
fibroblast growth factor receptor 1 [Source... |
U28938 |
5800 |
PTPRO |
protein tyrosine phosphatase receptor type ... |
U53505 |
1734 |
DIO2 |
iodothyronine deiodinase 2 [Source:HGNC Sym... |
U95178 |
1601 |
DAB2 |
DAB adaptor protein 2 [Source:HGNC Symbol;A... |
X53231 |
|
|
|
X54686 |
3726 |
JUNB |
JunB proto-oncogene, AP-1 transcription fac... |
X59859 |
1634 |
DCN |
decorin [Source:HGNC Symbol;Acc:HGNC:2705] |
X67788 |
7430 |
EZR |
ezrin [Source:HGNC Symbol;Acc:HGNC:12691] |
|
Version history |
3.1: First introduced
|
We need your help: Update on GSEA/MSigDB funding support
Last November we submitted a proposal to NCI's Information Technology for Cancer Research (ITCR) program for the continued
funding of GSEA and MSigDB. Unfortunately, our proposal was not funded in this round, but we were encouraged to resubmit
for the next one. This funding is critical for our continuing support and enhancement of the GSEA-MSigDB resource.
For our original submission many of you sent us emails of support, an important requirement for these grants. We
now ask for your help again. We would greatly appreciate a short email message from you describing how the resource
has been of value to your work and any concerns you may have about its continued availability.
Please send us your message of support to gsea-los@broadinstitute.org
on or before Monday June 5, 2023.
Thanks in advance for your help and support.
The GSEA/MSigDB Team.