Human Gene Set: AKT_UP_MTOR_DN.V1_DN


Standard name AKT_UP_MTOR_DN.V1_DN
Systematic name M2664
Brief description Genes down-regulated by everolimus [PubChem=6442177] in mouse prostate tissue transgenically expressing human AKT1 gene [GeneID=207] vs untreated controls.
Full description or abstract Transgenic (Probasin driven Myr-AKT) or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 hours following the beginning of treatment
Collection C6: Oncogenic Signature
Source publication Pubmed 15156201   Authors: Majumder PK,Febbo PG,Bikoff R,Berger R,Xue Q,McMahon LM,Manola J,Brugarolas J,McDonnell TJ,Golub TR,Loda M,Lane HA,Sellers WR
Exact source AKT_PLACEBO vs AKT_RAD001; bottom 150 genes (diff. of means)
Related gene sets (show 5 additional gene sets from the source publication)

(show 271 gene sets from the same authors)
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Organism Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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