Human Gene Set: BERGER_PLATELET_HYPERREACTIVITY_PRESS_DOWN


Standard name BERGER_PLATELET_HYPERREACTIVITY_PRESS_DOWN
Systematic name M49140
Brief description Genes down-regulated in patients with a hyperreactive platelet phenotype
Full description or abstract Platelets are key mediators of atherothrombosis, yet, limited tools exist to identify individuals with a hyperreactive platelet phenotype. In this study, we introduce a tool, the Platelet Reactivity ExpreSsion Score (PRESS), which integrates platelet aggregation responses and RNA sequencing. PRESS performs well in identifying a hyperreactive phenotype in patients with PAD (AUC [cross-validation] 0.81, 95% CI 0.68 -0.94, n = 84) and in an independent cohort of healthy participants (AUC [validation] 0.77, 95% CI 0.75 -0.79, n = 35). Following multivariable adjustment, PAD individuals with a PRESS score above the median are at higher risk for a future cardiovascular event (adjusted HR 1.90, CI 1.07?3.36; p = 0.027, n = 129). Incorporating PRESS into the analytical pipeline, PRESS was enriched in the platelet transcriptome of patients with versus without atherosclerosis. In conclusion, this study derives and validates the ability of PRESS to discriminate platelet hyperreactivity and identify those at increased cardiovascular risk.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 39164233   Authors: Berger JS,Cornwell MG,Xia Y,Muller MA,Smilowitz NR,Newman JD,Schlamp F,Rockman CB,Ruggles KV,Voora D,Hochman JS,Barrett TJ
Exact source Supplementary Table 7: PRESS Transcripts
Related gene sets (show 1 additional gene sets from the source publication)
External links https://pubmed.ncbi.nlm.nih.gov/39164233/
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Source species Homo sapiens
Contributed by Jeffrey S. Berger (New York University Grossman School of Medicine, New York, NY, USA)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2025.1.Hs: First Introduced.

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