Standard name |
CHEN_ETV5_TARGETS_SERTOLI |
Systematic name |
M1586 |
Brief description |
Genes down-regulated in Sertoli cells from both 4 and 10 week old ETV5 [GeneID=2119] knockout mice. |
Full description or abstract |
Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors. Here we show that the Ets related molecule (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 16107850 Authors: Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM |
Exact source |
Table 4S |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 138 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Mus musculus |
Contributed by |
John Newman (University of Washington) |
Source platform or identifier namespace |
MOUSE_SEQ_ACCESSION |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
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these 25 genes
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Gene families ? |
Categorize these
25 genes by gene family
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Show members |
(show 35 source identifiers mapped to 25 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AF128193 |
6354 |
CCL7 |
C-C motif chemokine ligand 7 [Source:HG... |
AF128196 |
6359 |
CCL15 |
C-C motif chemokine ligand 15 [Source:H... |
AF150963 |
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AF181829 |
5341 |
PLEK |
pleckstrin [Source:HGNC Symbol;Acc:HGNC... |
AF276754 |
2641 |
GCG |
glucagon [Source:HGNC Symbol;Acc:HGNC:4... |
AJ437645 |
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AK002748 |
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AK003524 |
411 |
ARSB |
arylsulfatase B [Source:HGNC Symbol;Acc... |
AK004192 |
948 |
CD36 |
CD36 molecule [Source:HGNC Symbol;Acc:H... |
AK005953 |
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AK011976 |
23452 |
ANGPTL2 |
angiopoietin like 2 [Source:HGNC Symbol... |
AW456869 |
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BB027251 |
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BB130348 |
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BB142076 |
57214 |
CEMIP |
cell migration inducing hyaluronidase 1... |
BB430142 |
57498 |
KIDINS220 |
kinase D interacting substrate 220 [Sou... |
BB787243 |
3487 |
IGFBP4 |
insulin like growth factor binding prot... |
BC019135 |
4321 |
MMP12 |
matrix metallopeptidase 12 [Source:HGNC... |
BE307351 |
948 |
CD36 |
CD36 molecule [Source:HGNC Symbol;Acc:H... |
BG069102 |
1993 |
ELAVL2 |
ELAV like RNA binding protein 2 [Source... |
BM247863 |
10620 |
ARID3B |
AT-rich interaction domain 3B [Source:H... |
L04961 |
7503 |
XIST |
X inactive specific transcript [Source:... |
M14216 |
2213 |
FCGR2B |
Fc gamma receptor IIb [Source:HGNC Symb... |
M37694 |
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NM_007651 |
963 |
CD53 |
CD53 molecule [Source:HGNC Symbol;Acc:H... |
NM_009141 |
6372 |
CXCL6 |
C-X-C motif chemokine ligand 6 [Source:... |
NM_009378 |
7056 |
THBD |
thrombomodulin [Source:HGNC Symbol;Acc:... |
NM_009777 |
713 |
C1QB |
complement C1q B chain [Source:HGNC Sym... |
NM_010188 |
2212 |
FCGR2A |
Fc gamma receptor IIa [Source:HGNC Symb... |
NM_013655 |
6387 |
CXCL12 |
C-X-C motif chemokine ligand 12 [Source... |
NM_019549 |
5341 |
PLEK |
pleckstrin [Source:HGNC Symbol;Acc:HGNC... |
NM_020008 |
64581 |
CLEC7A |
C-type lectin domain containing 7A [Sou... |
NM_026835 |
64231 |
MS4A6A |
membrane spanning 4-domains A6A [Source... |
NM_031168 |
3569 |
IL6 |
interleukin 6 [Source:HGNC Symbol;Acc:H... |
NM_053110 |
10457 |
GPNMB |
glycoprotein nmb [Source:HGNC Symbol;Ac... |
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Version history |
3.1: First introduced
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