Standard name |
CHEN_ETV5_TARGETS_TESTIS |
Systematic name |
M1664 |
Brief description |
Genes down-regulated in testis from 4 week old ETV5 [GeneID=2119] knockout mice. |
Full description or abstract |
Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors. Here we show that the Ets related molecule (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 16107850 Authors: Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM |
Exact source |
Table 1S |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 138 gene sets from the same authors)
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External links |
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Source species |
Mus musculus |
Contributed by |
John Newman (University of Washington) |
Source platform or identifier namespace |
MOUSE_SEQ_ACCESSION |
Dataset references |
(show 1 datasets)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
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these 25 genes
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Gene families ? |
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25 genes by gene family
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Show members |
(show 27 source identifiers mapped to 25 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AA866668 |
6658 |
SOX3 |
SRY-box transcription factor 3 [Source:H... |
AF091432 |
9134 |
CCNE2 |
cyclin E2 [Source:HGNC Symbol;Acc:HGNC:1... |
AI156310 |
8277 |
TKTL1 |
transketolase like 1 [Source:HGNC Symbol... |
AI197337 |
54801 |
HAUS6 |
HAUS augmin like complex subunit 6 [Sour... |
AI595812 |
133015 |
PACRGL |
parkin coregulated like [Source:HGNC Sym... |
AI596540 |
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AI606257 |
83879 |
CDCA7 |
cell division cycle associated 7 [Source... |
AI840713 |
284023 |
RNF227 |
ring finger protein 227 [Source:HGNC Sym... |
AJ223732 |
1017 |
CDK2 |
cyclin dependent kinase 2 [Source:HGNC S... |
AV357533 |
57820 |
CCNB1IP1 |
cyclin B1 interacting protein 1 [Source:... |
AW061337 |
205 |
AK4 |
adenylate kinase 4 [Source:HGNC Symbol;A... |
AW124460 |
1662 |
DDX10 |
DEAD-box helicase 10 [Source:HGNC Symbol... |
D13803 |
5888 |
RAD51 |
RAD51 recombinase [Source:HGNC Symbol;Ac... |
D25540 |
7046 |
TGFBR1 |
transforming growth factor beta receptor... |
D64107 |
11144 |
DMC1 |
DNA meiotic recombinase 1 [Source:HGNC S... |
D86725 |
4171 |
MCM2 |
minichromosome maintenance complex compo... |
L22977 |
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U25691 |
3070 |
HELLS |
helicase, lymphoid specific [Source:HGNC... |
U27177 |
5933 |
RBL1 |
RB transcriptional corepressor like 1 [S... |
U46694 |
1618 |
DAZL |
deleted in azoospermia like [Source:HGNC... |
U83902 |
4085 |
MAD2L1 |
mitotic arrest deficient 2 like 1 [Sourc... |
X15789 |
1381 |
CRABP1 |
cellular retinoic acid binding protein 1... |
X55316 |
4801 |
NFYB |
nuclear transcription factor Y subunit b... |
X77731 |
1633 |
DCK |
deoxycytidine kinase [Source:HGNC Symbol... |
X82786 |
4288 |
MKI67 |
marker of proliferation Ki-67 [Source:HG... |
Y15131 |
378948 |
RBMY1B |
RNA binding motif protein Y-linked famil... |
Z75287 |
346673 |
STRA8 |
stimulated by retinoic acid 8 [Source:HG... |
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Version history |
3.1: First introduced
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