Standard name |
CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_DN |
Systematic name |
M7910 |
Brief description |
Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112]. |
Full description or abstract |
To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 12704389 Authors: Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE |
Exact source |
Table 2S: HDMP DC < 0 & HDMP p val. < 0.01 |
Related gene sets |
(show 7 additional gene sets from the source publication)
(show 46 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U95 |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 25 genes
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Gene families ? |
Categorize these
25 genes by gene family
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Show members |
(show 25 source identifiers mapped to 25 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
1814_at |
7048 |
TGFBR2 |
transforming growth factor beta recepto... |
31838_at |
29902 |
FAM216A |
family with sequence similarity 216 mem... |
32102_at |
26278 |
SACS |
sacsin molecular chaperone [Source:HGNC... |
32117_at |
26574 |
AATF |
apoptosis antagonizing transcription fa... |
33706_at |
9092 |
SART1 |
spliceosome associated factor 1, recrui... |
33870_at |
51780 |
KDM3B |
lysine demethylase 3B [Source:HGNC Symb... |
34960_g_at |
2208 |
FCER2 |
Fc epsilon receptor II [Source:HGNC Sym... |
35963_at |
10471 |
PFDN6 |
prefoldin subunit 6 [Source:HGNC Symbol... |
35969_at |
10198 |
MPHOSPH9 |
M-phase phosphoprotein 9 [Source:HGNC S... |
36514_at |
10668 |
CGRRF1 |
cell growth regulator with ring finger ... |
37121_at |
4818 |
NKG7 |
natural killer cell granule protein 7 [... |
37130_g_at |
8620 |
NPFF |
neuropeptide FF-amide peptide precursor... |
37244_at |
7347 |
UCHL3 |
ubiquitin C-terminal hydrolase L3 [Sour... |
37662_at |
7326 |
UBE2G1 |
ubiquitin conjugating enzyme E2 G1 [Sou... |
38082_at |
23347 |
SMCHD1 |
structural maintenance of chromosomes f... |
38313_at |
20 |
ABCA2 |
ATP binding cassette subfamily A member... |
38713_at |
6721 |
SREBF2 |
sterol regulatory element binding trans... |
39307_s_at |
1212 |
CLTB |
clathrin light chain B [Source:HGNC Sym... |
40821_at |
191 |
AHCY |
adenosylhomocysteinase [Source:HGNC Sym... |
41246_at |
5270 |
SERPINE2 |
serpin family E member 2 [Source:HGNC S... |
41277_at |
10284 |
SAP18 |
Sin3A associated protein 18 [Source:HGN... |
41398_at |
64848 |
YTHDC2 |
YTH domain containing 2 [Source:HGNC Sy... |
41667_s_at |
23483 |
TGDS |
TDP-glucose 4,6-dehydratase [Source:HGN... |
41826_at |
57613 |
FAM234B |
family with sequence similarity 234 mem... |
579_at |
1060 |
CENPC |
centromere protein C [Source:HGNC Symbo... |
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Version history |
3.0: First introduced
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