Standard name |
CHEOK_RESPONSE_TO_MERCAPTOPURINE_UP |
Systematic name |
M19652 |
Brief description |
Genes specifically up-regulated in pediadric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490]. |
Full description or abstract |
To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 12704389 Authors: Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE |
Exact source |
Table 2S: MP DC > 0 & MP p val. < 0.01 |
Related gene sets |
(show 7 additional gene sets from the source publication)
(show 46 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Jean Junior (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U95 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 12 genes
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Gene families ? |
Categorize these
12 genes by gene family
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Show members |
(show 13 source identifiers mapped to 12 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
1199_at |
1973 |
EIF4A1 |
eukaryotic translation initiation factor... |
1939_at |
7157 |
TP53 |
tumor protein p53 [Source:HGNC Symbol;Ac... |
32251_at |
79921 |
TCEAL4 |
transcription elongation factor A like 4... |
35005_at |
10201 |
NME6 |
NME/NM23 nucleoside diphosphate kinase 6... |
35943_s_at |
2553 |
GABPB1 |
GA binding protein transcription factor ... |
36225_s_at |
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39637_at |
1836 |
SLC26A2 |
solute carrier family 26 member 2 [Sourc... |
39643_at |
11232 |
POLG2 |
DNA polymerase gamma 2, accessory subuni... |
40191_s_at |
23177 |
CEP68 |
centrosomal protein 68 [Source:HGNC Symb... |
40349_at |
84869 |
CBR4 |
carbonyl reductase 4 [Source:HGNC Symbol... |
40690_at |
1164 |
CKS2 |
CDC28 protein kinase regulatory subunit ... |
41415_at |
705 |
BYSL |
bystin like [Source:HGNC Symbol;Acc:HGNC... |
41462_at |
6643 |
SNX2 |
sorting nexin 2 [Source:HGNC Symbol;Acc:... |
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Version history |
3.0: Renamed from CHEOK_MP_UP
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