Human Gene Set: CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE

For the Mouse gene set with the same name, see CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE

Standard name CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE
Systematic name M427
Brief description Neurologically relevant transcripts with highest variance accounted for by mouse strain (genotype) differences.
Full description or abstract Patterns of gene expression in the central nervous system are highly variable and heritable. This genetic variation among normal individuals leads to considerable structural, functional and behavioral differences. We devised a general approach to dissect genetic networks systematically across biological scale, from base pairs to behavior, using a reference population of recombinant inbred strains. We profiled gene expression using Affymetrix oligonucleotide arrays in the BXD recombinant inbred strains, for which we have extensive SNP and haplotype data. We integrated a complementary database comprising 25 years of legacy phenotypic data on these strains. Covariance among gene expression and pharmacological and behavioral traits is often highly significant, corroborates known functional relations and is often generated by common quantitative trait loci. We found that a small number of major-effect quantitative trait loci jointly modulated large sets of transcripts and classical neural phenotypes in patterns specific to each tissue. We developed new analytic and graph theoretical approaches to study shared genetic modulation of networks of traits using gene sets involved in neural synapse function as an example. We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15711545   Authors: Chesler EJ,Lu L,Shou S,Qu Y,Gu J,Wang J,Hsu HC,Mountz JD,Baldwin NE,Langston MA,Threadgill DW,Manly KF,Williams RW
Exact source Table 1S
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(show 28 gene sets from any of these authors)
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Source species Mus musculus
Contributed by Jean Junior (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
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Version history 3.0: Renamed from CHESLER_BRAIN_HIGHEST_VARIANCE_GENES

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