Human Gene Set: DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC


Standard name DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC
Systematic name M47994
Brief description Matrisome proteins detected exclusively in highly proliferative head-and-neck squamous cell carcinoma human-to-mouse xenografts (T-Hep3) compared to dormant head-and-neck squamous cell carcinoma human-to-mouse xenografts (D-Hep3).
Full description or abstract By using ECM proteomics we have defined the matrisome of dormant cancer cells vs proliferative cancer cells of head and neck squamous cell carcinoma (HNSCC). To do so, we used established cellular dormancy models and their proliferative counterparts: proliferative (T-HEp3) and dormant (D-HEp3) HNSCC. To investigate the matrisome composition of these dormant and proliferative tumors, we performed ECM-enriched mass spectrometry using decellularized T-HEp3 tumors and D-HEp3 dormant nodules grown in mice. Analysis of indolent D-HEp3 dormant nodules and aggressive T-HEp3 tumors grown in mice show a significant dysregulation of the matrisome signature. This gene set lists the matrisome proteins detected exclusively in highly proliferative HNSCC human-to-mouse xenograft compared to dormant HNSCC human-to-mouse xenograft. We further excluded proteins that were detected in only one of the three proliferative samples.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 35121989   Authors: Di Martino JS,Nobre AR,Mondal C,Taha I,Farias EF,Fertig EJ,Naba A,Aguirre-Ghiso JA,Bravo-Cordero JJ
Exact source Supplemental Table S1 G
Related gene sets (show 1 additional gene sets from the source publication)

(show 31 gene sets from the same authors)
External links https://doi.org/10.1038/s43018-021-00291-9
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Source species Homo sapiens
Contributed by Alexandra Naba (University of Illinois Chicago)
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identifier namespace		 HUMAN_GENE_SYMBOL
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