Human Gene Set: EPPERT_LSC_R

Standard name EPPERT_LSC_R
Systematic name M19230
Brief description Genes up-regulated in functionally defined leukemic stem cells (LSC) from acute myeloid leukemia (AML) patients.
Full description or abstract Xenograft studies indicate that some solid tumors and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its relevance in humans remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSCs) using a sensitive xenograft assay. Analysis of gene expression from all functionally validated populations yielded an LSC-specific signature. Similarly, a hematopoietic stem cell (HSC) gene signature was established. Bioinformatic analysis identified a core transcriptional program shared by LSCs and HSCs, revealing the molecular machinery underlying stemness properties. Both stem cell programs were highly significant independent predictors of patient survival and were found in existing prognostic signatures. Thus, determinants of stemness influence the clinical outcome of AML, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 21873988   Authors: Eppert K,Takenaka K,Lechman ER,Waldron L,Nilsson B,van Galen P,Metzeler KH,Poeppl A,Ling V,Beyene J,Canty AJ,Danska JS,Bohlander SK,Buske C,Minden MD,Golub TR,Jurisica I,Ebert BL,Dick JE
Exact source Supplemental Table 7
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Source species Homo sapiens
Contributed by Kolja Eppert (McGill University)
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Version history 5.2: First introduced

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