Systematic name M41709
Brief description We identified three separate clusters (CL) of endothelial cells (CL7, CL9, CL16) expressing markers associated with lymph and blood vascular system (such as PECAM1, CD34, CTGF), but also associated with remodeling and inflammatory response (such as TXNIP, ANGPT2) (Fig. 3a-d). The DEGs of CL7 (such as CCL14, SOCS3, EGFL7) and CL16 (such as CCL21, TFF3) are linked to angiogenesis and lymphatics, respectively, while DEGs of CL9 (TM4SF1, NMMT) were more related to regulation of apoptosis (Fig. 3c, d).
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Collection C8: Cell Type Signature
Source publication Pubmed 31320652   Authors: Fan X,Bialecka M,Moustakas I,Lam E,Torrens-Juaneda V,Borggreven NV,Trouw L,Louwe LA,Pilgram GSK,Mei H,van der Westerlaken L,Chuva de Sousa Lopes SM
Exact source Supplementary Data 2 (complete underlying data received from authors), avg_logFC > 0.25, p_val_adj <0.05
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Organism Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: First Introduced.

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