Human Gene Set: FIGAROL_EGFR_TKI_DRUG_TOLERANT_CELL_DN


Standard name FIGAROL_EGFR_TKI_DRUG_TOLERANT_CELL_DN
Systematic name M49279
Brief description Genes commonly down-regulated (p<0.01, log2FC<0.5) in drug-tolerant cells that emerged in response to EGFR-TKI treatment (osimertinib or erlotinib) in at least 6 out 7 models of EGFR-mutant non-small cell lung cancer
Full description or abstract Drug-tolerance has emerged as one of the major non-genetic adaptive processes driving resistance to targeted therapies such as tyrosine kinase inhibitors (TKI) in non-small cell lung cancer (NSCLC). To identify potential hallmarks of drug-tolerant cells (DTC), we performed RNAseq and scRNAseq experiments using different models of EGFR-mutant DTC that emerged in response to EGFR-TKI (erlotinib or osimertinib) after 7-to-21 days of treatment. We combined our transcriptomic data with publicly available resources to generate a signature of drug-tolerance consisting in the most commonly overexpressed (p<0.01, Log2FC>0.5) or downregulated (p<0.01, Log2FC<0.5) genes in at least 6 out of 7 models.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38937474   Authors: Figarol S,Delahaye C,Gence R,Doussine A,Cerapio JP,Brachais M,Tardy C,Béry N,Asslan R,Colinge J,Villemin JP,Maraver A,Ferrer I,Paz-Ares L,Kessler L,Burrows F,Lajoie-Mazenc I,Dongay V,Morin C,Florent A,Pagano S,Taranchon-Clermont E,Casanova A,Pradines A,Mazieres J,Favre G,Calvayrac O
Exact source Supplementary Data 3
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External links https://www.nature.com/articles/s41467-024-49360-4
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Source species Homo sapiens
Contributed by Sarah Figarol, Celia Delahaye, Gilles Favre, Olivier Calvayrac (Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm, CNRS, Université de Toulouse, Université Toulouse III Paul Sabatier, Toulouse, France)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2025.1.Hs: First Introduced.

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