Human Gene Set: FIGAROL_EGFR_TKI_DRUG_TOLERANT_CELL_UP


Standard name FIGAROL_EGFR_TKI_DRUG_TOLERANT_CELL_UP
Systematic name M49278
Brief description Genes commonly up-regulated (p<0.01, log2FC>0.5) in drug-tolerant cells in response to EGFR-TKI treatment in at least 6 out 7 models of EGFR-mutant non-small cell lung cancer
Full description or abstract Drug-tolerance has emerged as one of the major non-genetic adaptive processes driving resistance to targeted therapies such as tyrosine kinase inhibitors (TKI) in non-small cell lung cancer (NSCLC). To identify potential hallmarks of drug-tolerant cells (DTC), we performed RNAseq and scRNAseq experiments using different models of EGFR-mutant DTC that emerged in response to EGFR-TKI (erlotinib or osimertinib) after 7-to-21 days of treatment. We combined our transcriptomic data with publicly available resources to generate a signature of drug-tolerance consisting in the most commonly overexpressed (p<0.01, Log2FC>0.5) or downregulated (p<0.01, Log2FC<0.5) genes in at least 6 out of 7 models.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38937474   Authors: Figarol S,Delahaye C,Gence R,Doussine A,Cerapio JP,Brachais M,Tardy C,Béry N,Asslan R,Colinge J,Villemin JP,Maraver A,Ferrer I,Paz-Ares L,Kessler L,Burrows F,Lajoie-Mazenc I,Dongay V,Morin C,Florent A,Pagano S,Taranchon-Clermont E,Casanova A,Pradines A,Mazieres J,Favre G,Calvayrac O
Exact source Supplementary Data 3
Related gene sets (show 1 additional gene sets from the source publication)

(show 6 gene sets from any of these authors)
External links https://www.nature.com/articles/s41467-024-49360-4
Filtered by similarity ?
Source species Homo sapiens
Contributed by Sarah Figarol, Celia Delahaye, Gilles Favre, Olivier Calvayrac (Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm, CNRS, Université de Toulouse, Université Toulouse III Paul Sabatier, Toulouse, France)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 4 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 212 genes
Gene families ? Categorize these 212 genes by gene family
Show members (show 212 source identifiers mapped to 212 genes)
Version history 2025.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.