| Standard name |
FONG_MCMASTER_OPA1_CARDIOPROTECTION_DN |
| Systematic name |
M50230 |
| Brief description |
Negative DEGs ( -1.5 > median log2 FC > -8, FDR < 0.01) with a partial least squares discriminant analysis (PLS-DA) VIP score >2 and Tuning Relief feature importance >0.2 |
| Full description or abstract |
This gene set is derived from human left ventricle transcriptomes in the GTEx database stratified into high and low OPA1 expression quintiles. The set members represent the intersection of highly significant downregulated genes identified through differential expression analysis (DEA) and those selected as predictive features by Partial Least Squares-Discriminant Analysis (PLS-DA) and Tuned ReliefF (TuRF). The resulting consensus signatures were validated in a mouse model of pressure overload induced by transverse aortic constriction (TAC) to evaluate their association with preserved cardiac function and metabolic signaling. |
| Collection |
C2: Curated
CGP: Chemical and Genetic Perturbations |
| Source publication |
Pubmed 41366320 Authors: Fong-McMaster C,Pulente SM,Kennedy LS,Smith TKT,Myers S,Kanaan MN,Karam CY,Cope M,Levesque MM,McIlroy E,Lorenzen-Schmidt I,Goergen CJ,Fullerton MD,Cuperlovic-Culf M,Mulvihill EE,Harper ME |
| Exact source |
Supplementary Material 2 (12872_2025_5413_MOESM2_ESM), Overlapping Genes, Negative DEGs, Overlap = True |
| Related gene sets |
(show 1 additional gene sets from the source publication)
|
| External links |
https://link.springer.com/article/10.1186/s12872-025-05413-0
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| Filtered by similarity ?
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| Source species |
Homo sapiens |
| Contributed by |
Anthony Castanza (MSigDB Team) |
Source platform or
identifier namespace |
Human_Ensembl_Gene_ID |
| Dataset references |
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| Download gene set |
format: grp | gmt | xml | json | TSV metadata |
| Compute overlaps ? |
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| Compendia expression profiles ? |
NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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| Advanced query |
Further investigate
these 19 genes
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| Gene families ? |
Categorize these
19 genes by gene family
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| Show members |
(show 31 source identifiers mapped to 19 genes)
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| Version history |
2026.1.Hs: First Introduced.
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