Human Gene Set: FOROUTAN_TGFB_EMT_DN


Standard name FOROUTAN_TGFB_EMT_DN
Systematic name M42502
Brief description Genes down-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets by combining results from an integrative approach and a product of ranks meta-analysis approach.
Full description or abstract Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer cell metastasis. EMT is induced by different stimuli, leading to different signaling patterns and therapeutic responses. TGF_ is one of the best-studied drivers of EMT, and many drugs are available to target this signaling pathway. A comprehensive bioinformatics approach was employed to derive a signature for TGF_-induced EMT which can be used to score TGF_-driven EMT in cells and clinical specimens. Multiple datasets were used to derive the signature using three approaches: by integrating the datasets prior to identifying EMT genes, by first identifying EMT genes from individual datasets and then combining them using a meta-analysis (product of ranks) approach, and by combining inferences from the first two approaches.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28119430   Authors: Foroutan M,Cursons J,Hediyeh-Zadeh S,Thompson EW,Davis MJ
Exact source Table S1. TGF_-EMT signature, https://doi.org/10.4225/49/5a2a11fa43fe3
Related gene sets (show 5 additional gene sets from the source publication)

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External links https://mcr.aacrjournals.org/highwire/filestream/36853/field_highwire_adjunct_files/2/1...
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Source species Homo sapiens
Contributed by Dharmesh D. Bhuva (Walter and Eliza Hall Institute of Medical Research)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history 7.5: First Introduced.

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