Human Gene Set: FOURATI_BLOOD_TWINRIX_AGE_65_81YO
      _RESPONDERS_VS_POOR_RESPONDERS_TRAINING
      _SET_0DY_NETWORK_INFERENCE_DN


Standard name FOURATI_BLOOD_TWINRIX_AGE_65_81YO_RESPONDERS_VS_POOR_RESPONDERS_TRAINING_SET_0DY_NETWORK_INFERENCE_DN
Systematic name M41017
Brief description Genes down-regulated in blood responders vs poor responders in seniors (65-81) (responders (training set)) after exposure to Twinrix , time point 0D. Comment: Network inference based on the 15 markers identified as predictors of the response to the HBV vaccine.
Full description or abstract Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine. In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine. Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine. A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve ~65%) but robust signature is supported by flow cytometry and cytokine profiling. This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26742691   Authors: Fourati S,Cristescu R,Loboda A,Talla A,Filali A,Railkar R,Schaeffer AK,Favre D,Gagnon D,Peretz Y,Wang IM,Beals CR,Casimiro DR,Carayannopoulos LN,Sékaly RP
Exact source Fig 4D
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729923/figure/f4/
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Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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