Human Gene Set: FOURATI_BLOOD_TWINRIX_AGE_65_83YO_POOR
      _RESPONDERS_VS_RESPONDERS_0DY_NETWORK
      _INFERENCE_UP


Standard name FOURATI_BLOOD_TWINRIX_AGE_65_83YO_POOR_RESPONDERS_VS_RESPONDERS_0DY_NETWORK_INFERENCE_UP
Systematic name M41046
Brief description Genes up-regulated in blood poor responders vs responders in seniors (65-83) (poor responders) after exposure to Twinrix , time point 0D. Comment: Networks were inferred for the BioAge module 1 combined to the 15-gene signature and the BioAge module 16 combined to the 15-gene signature, respectively.
Full description or abstract Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine. In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine. Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine. A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve ~65%) but robust signature is supported by flow cytometry and cytokine profiling. This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26742691   Authors: Fourati S,Cristescu R,Loboda A,Talla A,Filali A,Railkar R,Schaeffer AK,Favre D,Gagnon D,Peretz Y,Wang IM,Beals CR,Casimiro DR,Carayannopoulos LN,Sékaly RP
Exact source Discussion; Fig 4E
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729923/figure/f4/
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Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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