Standard name |
FOURNIER_ACINAR_DEVELOPMENT_LATE_DN |
Systematic name |
M13202 |
Brief description |
Genes down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. |
Full description or abstract |
Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growth-arrested HMECs would share similarities with breast tumors with good prognoses. Using Affymetrix HG-U133A microarrays, we analyzed the expression of 22,283 gene transcripts in 184 (finite life span) and HMT3522 S1 (immortal nonmalignant) HMECs on successive days after seeding in a lrECM assay. Both HMECs underwent growth arrest in G0-G1 and differentiated into polarized acini between days 5 and 7. We identified gene expression changes with the same temporal pattern in both lines and examined the expression of these genes in a previously published panel of microarray data for 295 breast cancer samples. We show that genes that are significantly lower in the organized, growth-arrested HMEC than in their proliferating counterparts can be used to classify breast cancer patients into poor and good prognosis groups with high accuracy. This study represents a novel unsupervised approach to identifying breast cancer markers that may be of use clinically. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 16849555 Authors: Fournier MV,Martin KJ,Kenny PA,Xhaja K,Bosch I,Yaswen P,Bissell MJ |
Exact source |
Table 1S: dl |
Related gene sets |
(show 4 additional gene sets from the source publication)
(show 18 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
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these 22 genes
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Gene families ? |
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22 genes by gene family
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Show members |
(show 22 source identifiers mapped to 22 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200790_at |
4953 |
ODC1 |
ornithine decarboxylase 1 [Source:HGN... |
200801_x_at |
60 |
ACTB |
actin beta [Source:HGNC Symbol;Acc:HG... |
201714_at |
7283 |
TUBG1 |
tubulin gamma 1 [Source:HGNC Symbol;A... |
202580_x_at |
2305 |
FOXM1 |
forkhead box M1 [Source:HGNC Symbol;A... |
203499_at |
1969 |
EPHA2 |
EPH receptor A2 [Source:HGNC Symbol;A... |
203856_at |
7443 |
VRK1 |
VRK serine/threonine kinase 1 [Source... |
204014_at |
1846 |
DUSP4 |
dual specificity phosphatase 4 [Sourc... |
204033_at |
9319 |
TRIP13 |
thyroid hormone receptor interactor 1... |
204092_s_at |
6790 |
AURKA |
aurora kinase A [Source:HGNC Symbol;A... |
204170_s_at |
1164 |
CKS2 |
CDC28 protein kinase regulatory subun... |
205014_at |
9982 |
FGFBP1 |
fibroblast growth factor binding prot... |
206467_x_at |
8771 |
TNFRSF6B |
TNF receptor superfamily member 6b [S... |
208637_x_at |
87 |
ACTN1 |
actinin alpha 1 [Source:HGNC Symbol;A... |
209714_s_at |
1033 |
CDKN3 |
cyclin dependent kinase inhibitor 3 [... |
209773_s_at |
6241 |
RRM2 |
ribonucleotide reductase regulatory s... |
212190_at |
5270 |
SERPINE2 |
serpin family E member 2 [Source:HGNC... |
214805_at |
1973 |
EIF4A1 |
eukaryotic translation initiation fac... |
218349_s_at |
55055 |
ZWILCH |
zwilch kinetochore protein [Source:HG... |
218456_at |
65981 |
CAPRIN2 |
caprin family member 2 [Source:HGNC S... |
218542_at |
55165 |
CEP55 |
centrosomal protein 55 [Source:HGNC S... |
218663_at |
64151 |
NCAPG |
non-SMC condensin I complex subunit G... |
219918_s_at |
259266 |
ASPM |
assembly factor for spindle microtubu... |
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Version history |
3.0: First introduced
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