Human Gene Set: FRANCO_BLOOD_SANOFI_PASTEUR_SA
      _INACTIVATED_INFLUENZA_VACCINE
      _CORRELATED_WITH_ANTIBODY_RESPONSE_AGE
      _18_40YO_14DY_NEGATIVE


Standard name FRANCO_BLOOD_SANOFI_PASTEUR_SA_INACTIVATED_INFLUENZA_VACCINE_CORRELATED_WITH_ANTIBODY_RESPONSE_AGE_18_40YO_14DY_NEGATIVE
Systematic name M41090
Brief description Genes negatively correlated with antibody response in blood in adults (18-40) after exposure to Sanofi Pasteur, SA, Inactivated influenza vaccine , time point 14D
Full description or abstract Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI:http://dx.doi.org/10.7554/eLife.00299.001.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 23878721   Authors: Franco LM,Bucasas KL,Wells JM,Niņo D,Wang X,Zapata GE,Arden N,Renwick A,Yu P,Quarles JM,Bray MS,Couch RB,Belmont JW,Shaw CA
Exact source Suppl File 1, Table 3
Related gene sets (show 6 additional gene sets from the source publication)

(show 2542 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/bin/elife-00299-supp1.xlsx
Filtered by similarity ?
Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 28 genes
Gene families ? Categorize these 28 genes by gene family
Show members (show 28 source identifiers mapped to 28 genes)
Version history 7.3: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.