Human Gene Set: GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE

For the Mouse gene set with the same name, see GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE

Standard name GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE
Systematic name M42776
Brief description The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0036499
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0036499
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.

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