Human Gene Set: GOBP_PHOSPHOLIPASE_C_PROTEIN_KINASE_C_SIGNAL_TRANSDUCTION

For the Mouse gene set with the same name, see GOBP_PHOSPHOLIPASE_C_PROTEIN_KINASE_C_SIGNAL_TRANSDUCTION

Standard name GOBP_PHOSPHOLIPASE_C_PROTEIN_KINASE_C_SIGNAL_TRANSDUCTION
Systematic name M49585
Brief description An intracellular signaling cassette that starts with activation of phospholipase C (PLC) activity and ends with the activation of protein kinase C (PKC). PLC produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. This cassette is often part of the phospholipase C-activating G protein-coupled receptor signaling pathway. [PMID:26605346]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0141212
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0141212
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.

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