Human Gene Set: GOBP_REPLICATIVE_SENESCENCE

For the Mouse gene set with the same name, see GOBP_REPLICATIVE_SENESCENCE

Standard name GOBP_REPLICATIVE_SENESCENCE
Systematic name M14683
Brief description The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. [PMID:17014937, PMID:23061726]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0090399
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0090399
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2025.1.Hs: Updated to GO Release 2025-03-16.

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