Human Gene Set: GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX

For the Mouse gene set with the same name, see GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX

Standard name GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX
Systematic name M25860
Brief description A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present. [GOC:mah, PMID:10745006]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0045240
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0045240
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: Updated to GO Release 2025-10-10.


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