Human Gene Set: GOCC_RIXOSOME_COMPLEX

For the Mouse gene set with the same name, see GOCC_RIXOSOME_COMPLEX

Standard name GOCC_RIXOSOME_COMPLEX
Systematic name M50623
Brief description A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans. [GOC:vw, PMID:32491985, PMID:35355014]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0120330
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0120330
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
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Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2026.1.Hs: Updated to GO Release 2025-10-10.


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