Human Gene Set: GOLDRATH_ANTIGEN_RESPONSE

For the Mouse gene set with the same name, see GOLDRATH_ANTIGEN_RESPONSE

Standard name GOLDRATH_ANTIGEN_RESPONSE
Systematic name M11884
Brief description Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells.
Full description or abstract Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15548615   Authors: Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D
Exact source Table 1S
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(show 349 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: First introduced

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