Human Gene Set: GOMF_P_TYPE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

For the Mouse gene set with the same name, see GOMF_P_TYPE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

Standard name GOMF_P_TYPE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY
Systematic name M40681
Brief description Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. [PMID:18075584, PMID:25918123]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:MF: GO Molecular Function
Source publication  
Exact source GO:0140358
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0140358
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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