Human Gene Set: GSE14413_UNSTIM_VS_IFNB_STIM_L929_CELLS_UP


Standard name GSE14413_UNSTIM_VS_IFNB_STIM_L929_CELLS_UP
Systematic name M473
Brief description Genes up-regulated in L929 cells (fibroblast): control versus stimulated with IFN-b.
Full description or abstract Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-?-induced transcripts. We identified DSIRE (DNA sensor for the IL-1? response, previously called AIM2) as a candidate cytoplasmic sensor. DSIRE showed a marked selectivity for double-stranded DNA. DSIRE can recruit the inflammasome adaptor ASC and gets redistributed to ASC speckles upon coexpression of ASC. RNAi-mediated reduction of DSIRE expression led to an impairment in IL-1? maturation. Reconstitution of unresponsive cells with DSIRE, ASC, caspase 1 and IL-1? showed that DSIRE is sufficient for inflammasome activation. Overall, our data strongly suggest that DSIRE is a cytoplasmic DNA sensor for the inflammasome.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19158679   Authors: Bürckstümmer T,Baumann C,Blüml S,Dixit E,Dürnberger G,Jahn H,Planyavsky M,Bilban M,Colinge J,Bennett KL,Superti-Furga G
Exact source GSE14413_1128_200_UP
Related gene sets (show 5 additional gene sets from the source publication)

(show 12 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 123 genes
Gene families ? Categorize these 123 genes by gene family
Show members (show 200 source identifiers mapped to 123 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.