Human Gene Set: GSE14769_40MIN_VS_360MIN_LPS_BMDM_DN

Standard name GSE14769_40MIN_VS_360MIN_LPS_BMDM_DN
Systematic name M3517
Brief description Genes down-regulated in comparison of macrophage cells stimulated with LPS (TLR4 agonist) for 40 min versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.
Full description or abstract The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-?B, C/EBP?, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-?B), an amplifier (C/EBP?) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19270711   Authors: Litvak V,Ramsey SA,Rust AG,Zak DE,Kennedy KA,Lampano AE,Nykter M,Shmulevich I,Aderem A
Exact source GSE14769_1137_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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